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MAGL-IN-4

MAGL-IN-4
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MAGL-IN-4

Catalog No. T9687Cas No. 2135785-20-3
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$159In Stock
5 mg$396In Stock
10 mg$589In Stock
25 mg$945In Stock
50 mg$1,280In Stock
100 mg$1,730In Stock
500 mg$3,460In Stock
1 mL x 10 mM (in DMSO)$446In Stock
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Product Introduction

Bioactivity
Description
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
In vitro
MAGL-IN-4 showed potent in vitro MAGL inhibitory activity (IC50 6.2 nM), good oral absorption and blood-brain barrier penetration[1].
In vivo
MAGL-IN-4 showed significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3-10 mg/kg, po. in mice[1].
AliasHis121 ARG57
Chemical Properties
Molecular Weight364.82
FormulaC18H21ClN2O4
Cas No.2135785-20-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 88 mg/mL (241.21 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7411 mL13.7054 mL27.4108 mL137.0539 mL
5 mM0.5482 mL2.7411 mL5.4822 mL27.4108 mL
10 mM0.2741 mL1.3705 mL2.7411 mL13.7054 mL
20 mM0.1371 mL0.6853 mL1.3705 mL6.8527 mL
50 mM0.0548 mL0.2741 mL0.5482 mL2.7411 mL
100 mM0.0274 mL0.1371 mL0.2741 mL1.3705 mL

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