Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 60.00 | |
10 mg | In stock | $ 91.00 | |
25 mg | In stock | $ 195.00 | |
50 mg | In stock | $ 346.00 | |
100 mg | In stock | $ 512.00 | |
500 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
Targets&IC50 | GPR139:16 Nm(EC50) |
In vitro | JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. JNJ-63533054 is found to be clean of any cross reactivity as judged by an external selectivity panel of 50 known GPCRs, ion channels, and transporters as well as our own internal whole cell lead generation biology selectivity panel. |
In vivo | JNJ-63533054 is found to cross the blood-brain barrier and have good drug-like properties amenable for oral dosing in rat. JNJ-63533054 exhibits good stability in both human and rat microsomes and high solubility in aqueous media, and no DDI potential was found. JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM). |
Synonyms | JNJ 63533054 |
Molecular Weight | 316.78 |
Formula | C17H17ClN2O2 |
CAS No. | 1802326-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.7 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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JNJ-63533054 1802326-66-4 Endocrinology/Hormones GPCR/G Protein GPR L-tryptophan blood-brain oral CNS L-phenylalanine G Protein-Coupled Receptor 139 barrier JNJ 63533054 Inhibitor GPR139 inhibit JNJ63533054 inhibitor