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FAUC 213

Catalog No. T24055 CAS 337972-47-1

Synonyms: FAUC213, FAUC-213

FAUC 213 is a selective full antagonist of the dopamine D4 receptor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

FAUC 213, CAS 337972-47-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00

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Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FAUC 213 is a selective full antagonist of the dopamine D4 receptor.
Targets&IC50	D3 receptor (human):5.3 μM (Ki), D2 receptor (human):3.4 μM (Ki), D4.4 receptor (human):2.2 nM (Ki)

Synonyms	FAUC213, FAUC-213
Molecular Weight	326.82
Formula	C18H19ClN4
CAS No.	337972-47-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.26 mg/mL (9.99 mM)

References and Literature

1. Stößel A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P. Development of molecular tools based on the dopamine D(3) receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorg Med Chem. 2017 Jul 1;25(13):3491-3499. doi: 10.1016/j.bmc.2017.04.036. Epub 2017 Apr 29. PubMed PMID: 28495386; PubMed Central PMCID: PMC5512454. 2. Janhunen SK, la Fleur SE, Adan RA. Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats. Obesity (Silver Spring). 2013 Dec;21(12):E700-8. doi: 10.1002/oby.20581. Epub 2013 Sep 5. PubMed PMID: 23894096. 3. Sanna F, Corda MG, Melis MR, Piludu MA, Löber S, Hübner H, Gmeiner P, Argiolas A, Giorgi O. Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats. Pharmacol Biochem Behav. 2013 Aug;109:59-66. doi: 10.1016/j.pbb.2013.05.002. Epub 2013 May 8. PubMed PMID: 23664901. 4. Prante O, Tietze R, Hocke C, Löber S, Hübner H, Kuwert T, Gmeiner P. Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. J Med Chem. 2008 Mar 27;51(6):1800-10. doi: 10.1021/jm701375u. Epub 2008 Feb 29. PubMed PMID: 18307287.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Orally Active Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Parkinson's Disease Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FAUC 213 337972-47-1 GPCR/G Protein Neuroscience Dopamine Receptor inhibit p5-HT2 orally pα1 BBB AMPH barrier amphetamin blood-brain Inhibitor FAUC213 p5-HT1 FAUC-213 antipsychotic inhibitor

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