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Domperidone

Domperidone
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Purity:99.73%
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Domperidone

Catalog No. T0082Cas No. 57808-66-9
Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
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Pack SizePriceAvailabilityQuantity
50 mg$38In Stock
100 mg$54In Stock
200 mg$91In Stock
500 mg$148In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
In vitro
Domperidone (a D2R antagonist) inhibits Equilibrative NT1 (ENT1) activity more in the presence than in the absence of Bromocriptine and displays an IC50 value lower than that of Bromocriptine or Ergovaline in Madin-Darby bovine kidney (MDBK) cells. [1]
In vivo
Domperidone (0.1 mg/kg) results in a significant decrease in feeding behavior and stimulation of basal metabolism, but has no effect on locomotor activity of rats in a Phenomaster system. [2] Domperidone (1.1 mg/kg and 5.5 mg/kg, oral) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, beginning 4 hours after administration, and this effect persisted for at least 8 hours. Domperidone (0.2 mg/kg, i.v.) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, at 10 and 12 hours after administration. [3] Domperidone can ameliorate deleterious reproductive effects and reduce weight gain associated with fescue toxicosis in heifers. [4] Domperidone-treated mares have shorter gestation duration and foaled closer to their expected parturition date than did control mares. Domperidone-treated mares have higher Mammary gland scores and serum prolactin concentration. [5] Domperidone (5 mg/kg, oral) increases peak plasma acetaminophen concentration and area under the curve in rats, indicating increased gastric emptying. Domperidone decreases the dopamine-induced contractile activity of midjejunal longitudinal muscle strips in rats. [6]
AliasR33812
Chemical Properties
Molecular Weight425.91
FormulaC22H24ClN5O2
Cas No.57808-66-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 42.6 mg/mL (100 mM)
1eq. HCl: 2.1 mg/mL (5 mM)
Solution Preparation Table
DMSO/1eq. HCl
1mg5mg10mg50mg
1 mM2.3479 mL11.7396 mL23.4791 mL117.3957 mL
DMSO
1mg5mg10mg50mg
5 mM0.4696 mL2.3479 mL4.6958 mL23.4791 mL
10 mM0.2348 mL1.1740 mL2.3479 mL11.7396 mL
20 mM0.1174 mL0.5870 mL1.1740 mL5.8698 mL
50 mM0.0470 mL0.2348 mL0.4696 mL2.3479 mL
100 mM0.0235 mL0.1174 mL0.2348 mL1.1740 mL

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