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Metoprine

Catalog No. T8548   CAS 7761-45-7

Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.

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Metoprine Chemical Structure
Metoprine, CAS 7761-45-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 55.00
10 mg In stock $ 89.00
25 mg In stock $ 159.00
50 mg In stock $ 263.00
100 mg In stock $ 397.00
500 mg In stock $ 913.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.09%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
In vivo In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.?Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.?Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose[1].
Molecular Weight 269.13
Formula C11H10Cl2N4
CAS No. 7761-45-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL (14.86 mM)

TargetMolReferences and Literature

1. Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7. 2. Samotaeva I S , Birioukova L M , Midzyanovskaya I S , et al. Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats[J]. Epilepsy Research, 2012, 101(1-2):148-156.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compound Library Bioactive Compounds Library Max Histamine & Melatonin Receptor-Targeted Compound Library Epigenetics Compound Library ReFRAME Related Library Methylation Compound Library Neuronal Signaling Compound Library Immunology/Inflammation Compound Library Neurotransmitter Receptor Compound Library

Related Products

Related compounds with same targets
PF-03654746 Cyclizine dihydrochloride Corchoionoside C Cetirizine D8 H4R antagonist 3 Dothiepin H4R antagonist 2 4-Methylhistamine

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Keywords

Metoprine 7761-45-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Antifolate Histone Methyltransferase Inhibitor histamine HMT barrier antitumor N-methyltransferase diaminopyrimidine inhibit BW 197U blood-brain inhibitor

 

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