Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 105.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 397.00 | |
500 mg | In stock | $ 913.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R). |
Targets&IC50 | OX2:8.0 (pki)(human), OX2:8.1 (pki)(rat) |
In vivo | Seltorexant (3-30 mg/kg; p.o.) dose-dependently causes and prolongs sleep in male Sprague-Dawley rats. The sleep-promoting effects of Seltorexant (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats [1]. |
Synonyms | JNJ-42847922 |
Molecular Weight | 407.44 |
Formula | C21H22FN7O |
CAS No. | 1293281-49-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (613.59 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Seltorexant 1293281-49-8 GPCR/G Protein Neuroscience OX Receptor Hypocretin Receptor HCRT Receptor Orexin Receptor (OX Receptor) movement barrier JNJ 42847922 insomnia somnolence eye blood-brain inhibit rapid JNJ42847922 JNJ-42847922 selective sleep Inhibitor inhibitor