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TTK21

Catalog No. T8778 CAS 709676-56-2

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

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TTK21, CAS 709676-56-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 413.00
50 mg	In stock	$ 618.00
100 mg	In stock	$ 879.00
500 mg	In stock	$ 1,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 99.3%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

In vivo

a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

Molecular Weight	357.75
Formula	C17H15ClF3NO2
CAS No.	709676-56-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (69.88 mM)

References and Literature

1. Chatterjee, S., Mizar, P., Cassel, R., et al. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J. Neurosci. 33(26), 10698-10712 (2013).

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library Epigenetics Compound Library PPI Inhibitor Library Histone Modification Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TTK21 709676-56-2 Chromatin/Epigenetic Epigenetic Reader Domain TTK-21 HAT histone acetyltransferases neurogenesis blood–brain barrier HATs TTK 21 inhibit Histone Acetyltransferase Inhibitor long-term memory toxicity CSP CBP/p300 inhibitor

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