artery — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN6715	7-Ketocholesterol		Others
	7-Ketocholesterol is a metabolite of Cholesterol		Others
T9023	Atuliflapon	AZD5718	FLAP
	Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.		FLAP
T6792	BQ-123	BQ123	Endothelin Receptor
	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.		Endothelin Receptor
T4330	CaCCinh-A01		Chloride channel
	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).		Chloride channel
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T6033	Zotarolimus	ABT-578,A 179578	mTOR
	Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).		mTOR
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T6951	Pramipexole dihydrochloride hydrate	Pramipexole 2HCl Monohydrate,Mirapex	Dopamine Receptor
	Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...		Dopamine Receptor
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T0154	Nebivolol hydrochloride	R 065824 hydrochloride,Nebivolol HCl,R-65824	Apoptosis , Adrenergic Receptor
	Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us...		Apoptosis , Adrenergic Receptor
TWA2417	Sodium taurocholate	Taurocholate Sodium	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and...		Others
T19345	GP2-114		Others
	GP2-114 is a catecholamine exercise mimetic that can be used to study coronary artery disease (CAD).		Others
T2480	Apabetalone	RVX-208,RVX000222	Epigenetic Reader Domain , HIV Protease
	Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.		Epigenetic Reader Domain , HIV Protease
T1986	Atopaxar	E5555,ER-172594-00	Protease-activated Receptor
	Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T10595	BQ-788	BQ788	Endothelin Receptor
	BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press...		Endothelin Receptor
T1986L	Atopaxar Hydrobromide		Protease-activated Receptor
	Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.		Protease-activated Receptor
T23557	Talibegron hydrochloride	ZD2079 hydrochloride,ZD 2079	Adrenergic Receptor
	Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. In...		Adrenergic Receptor
T24873	TGX-115	TGX 115	PI3K
	TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3...		PI3K