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CaCCinh-A01

Catalog No. T4330 CAS 407587-33-1

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).

CaCCinh-A01, CAS 407587-33-1

Pack Size	Availability	Price/USD
5 mg	In stock	58.00
10 mg	In stock	107.00
25 mg	In stock	224.00
50 mg	In stock	400.00
100 mg	In stock	711.00
200 mg	In stock	995.00
1 mL * 10 mM (in DMSO)	In stock	64.00

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Purity 99.92%

HNMR HPLC COA Datasheet MSDS

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Storage & Solubility Information

Description	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Targets&IC50	TMEM16A, CaCC,
Cell Research	Each well of a 96-well plate is washed three times with PBS (200 μL/wash), leaving 50 μL of PBS. Test compounds (including CaCCinh-A01) (0.5 μL) are added to each well at 25 μM final concentration. After 10 min, 96-well plates are transferred to a plate reader for fluorescence assay. Each well is assayed individually for TMEM16A-mediated I- influx by recording fluorescence continuously (400 ms/point) for 2 s (baseline), then 50 μL of a 140 mM I-solution containing 200 μM ATP is added.

Molecular Weight	347.43
Formula	C18H21NO4S
CAS No.	407587-33-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Namkung W,etal.TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloridechannel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74. 2. De La Fuente R, et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloridechannel. Mol Pharmacol. 2008 Mar;73(3):758-68.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-cancer Compound Library

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.