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Atopaxar

Catalog No. T1986   CAS 751475-53-3
Synonyms: E5555, ER-172594-00

Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.

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Atopaxar Chemical Structure
Atopaxar, CAS 751475-53-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 67.00
5 mg In stock $ 139.00
10 mg In stock $ 255.00
25 mg In stock $ 463.00
50 mg In stock $ 682.00
100 mg In stock $ 969.00
1 mL * 10 mM (in DMSO) In stock $ 159.00
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Purity: 98.5%
Purity: 98.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
Kinase Assay Kinase assays: WHI-P154 is tested in kinase assays. The panel of kinases is selected to broadly cover the kinome, providing a good approximation of specificity. For all kinases, recombinant rat (IKKβ) or human (all others), full-length or GST-kinase domain fusion proteins, are used. WHI-P154 is inactive (concentration that inhibits response by 50% [IC50] > 30 μM) for the following kinases: AKT, AuroraA, cdk2, cdk6, CHK1, FGFR1, GSK3b, IKKb, IKKi, INSR, MAPK1, MAPKAP-K2, MASK, MET, PAK4, PDK1, PKCb, ROCK1, TaoK3, TrkA.
Synonyms E5555, ER-172594-00
Molecular Weight 527.63
Formula C29H38FN3O5
CAS No. 751475-53-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (47.38 mM)

TargetMolReferences and Literature

1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Anti-Obesity Compound Library Drug Repurposing Compound Library Inhibitor Library GPCR Compound Library Clinical Compound Library Bioactive Compound Library

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Keywords

Atopaxar 751475-53-3 GPCR/G Protein Protease-activated Receptor platelets receptor-1 signaling PAR-1 E5555 inhibit E-5555 Inhibitor receptor Protease Activated Receptor (PAR) protease-activated atherothrombotic thrombin E 5555 Thrombin receptors ER-172594-00 inhibitor

 

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