Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 72.00 | |
50 mg | In stock | $ 119.00 | |
100 mg | In stock | $ 173.00 | |
500 mg | In stock | $ 429.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease. |
Targets&IC50 | BD2:0.51 μM |
In vitro | In AGMs, RVX-208 significantly increases serum apoA-I and HDL-C levels and enhances cholesterol efflux through various pathways. |
In vivo | In vitro studies have demonstrated that RVX-208 activates the expression of the apolipoprotein AI gene, leading to an increase in apoA-I and HDL-C levels. Additionally, RVX-208 inhibits BET bromodomain proteins, exhibiting a preferential binding to the second bromodomain of BET proteins. |
Cell Research | RVX-208 is prepared in DMSO and stored, and then diluted with appropriate medium before use[2]. Huh7 cells are plated at 23,000/well in a 96 well plate in DMEM+10% FBS before allowing to grow overnight. Cells are treated with compounds for 48 h in 0.1% DMSO with or without 5 μM Actinomycin D. U937 cells are differentiated for 3 days in 60 ng/mL PMA, 32,000 cells/well in 96-well format. Cells are then treated with compound in 0.1% DMSO in RPMI media+10% FBS, and after 1 h, lipopolysaccharide is added to the cells at 1 μg/mL for 3 hours[2]. |
Synonyms | RVX-208, RVX000222 |
Molecular Weight | 370.4 |
Formula | C20H22N2O5 |
CAS No. | 1044870-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Apabetalone 1044870-39-4 Chromatin/Epigenetic Microbiology/Virology Proteases/Proteasome Epigenetic Reader Domain HIV Protease RVX-208 RVX-000222 Inhibitor RVX000222 RVX 000222 RVX208 Human immunodeficiency virus inhibit RVX 208 HIV inhibitor