Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Ketocholesterol is a metabolite of Cholesterol
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 57.00 | |
25 mg | In stock | $ 216.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 67.00 |
Description | 7-Ketocholesterol is a metabolite of Cholesterol |
In vivo | 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.?7KC induces a dose-dependent loss of cell viability and an increase in apoptosis and necrosis in the endothelial cells.?A relocalization of the tight junction proteins, zonula occludens-1 (ZO-1) and claudin-5, towards the nucleus of the cells was also observed.?These effects were significantly attenuated by ET. In addition, 7KC induces marked increases in the mRNA expression of pro-inflammatory cytokines, IL-1β IL-6, IL-8, TNF-α and cyclooxygenase-2 (COX2), as well as COX2 enzymatic activity, and these were significantly reduced by ET. |
Molecular Weight | 400.65 |
Formula | C27H44O2 |
CAS No. | 566-28-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 4.01mg (10 mM)
You can also refer to dose conversion for different animals. More
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7-Ketocholesterol 566-28-9 Others HMG-CoA reductase inhibit 7 Ketocholesterol Endogenous Metabolite Inhibitor coronary artery disease 7Ketocholesterol cholesterol biosynthesis orphan disease inhibitor