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Talibegron hydrochloride

Catalog No. T23557   CAS 178600-17-4
Synonyms: ZD2079 hydrochloride, ZD 2079

Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.

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Talibegron hydrochloride Chemical Structure
Talibegron hydrochloride, CAS 178600-17-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 49.00
5 mg In stock $ 109.00
10 mg In stock $ 135.00
25 mg In stock $ 298.00
50 mg In stock $ 433.00
100 mg In stock $ 592.00
500 mg In stock $ 1,180.00
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Purity: 99.82%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
In vitro Talibegron hydrochloride ( 0.01-1000 μM) produces a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries and causes full relaxation with 1 mM[1].
In vivo The β3-adrenoceptor agonist talibegron hydrochloride produced a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries. The shape of the concentration–response curve of talibegron hydrochloride also suggests that this drug, which was studied up to 1 mm, causes full relaxation [3].
Synonyms ZD2079 hydrochloride, ZD 2079
Molecular Weight 351.83
Formula C18H22ClNO4
CAS No. 178600-17-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 8.8 mg/mL

DMSO: 50 mg/mL (142.11 mM)

TargetMolReferences and Literature

1. Hanna Kozłowska, et al. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol. 2003 Sep;140(1):3-12. 2. Brawley L, et al. Role of endothelium/nitric oxide in atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta. Eur J Pharmacol. 2000 Jun 16;398(2):285-96. 3. Kozłowska H, et al. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol. 2003 Sep;140(1):3-12.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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Nylidrin hydrochloride nifenalol.HCl Terazosin hydrochloride (4E)-SUN9221 (±)-N-Methylcoclaurine AVN-101 Brexpiprazole Dabelotine

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Keywords

Talibegron hydrochloride 178600-17-4 GPCR/G Protein Neuroscience Adrenergic Receptor Talibegron Hydrochloride ZD2079 hydrochloride ZD2079 ZD2079 Hydrochloride ZD 2079 ZD-2079 Hydrochloride ZD 2079 Hydrochloride ZD-2079 inhibitor inhibit

 

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