apparent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12855	SB 258719		5-HT Receptor
	SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).		5-HT Receptor
T11303	Fluorobexarotene		Retinoid Receptor
	Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RX...		Retinoid Receptor
T70038	MJN68390		Caspase
	MJN68390 has an apparent IC50 value of 15 μM against CASP8 and shows no activity against CASP10.		Caspase
T14988	CMPD1		MAPK
	CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).		MAPK
T6452	Closantel Sodium		Antibacterial , Parasite
	Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.		Antibacterial , Parasite
T7045	Clonidine	Nexiclon,Catapres,Kapvay	Adrenergic Receptor
	Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide-scale use for many years, clonidine has not been l...		Adrenergic Receptor
TN6764	Simmondsin		Others
	Simmondsin is a natural product from Simmondsia chinensis -- jojoba. It reduced food intake and body weight without apparent negative effects in rats.		Others
T0226	Betaxolol hydrochloride	SL75212,SL 75212 HCl,Betaxolol HCl	Adrenergic Receptor
	Betaxolol hydrochloride (SL 75212 HCl) is a cardioselective beta-blocker used in the treatment of hypertension.Betaxolol hydrochloride has not been linked to instances of clinically apparent drug induced liver injury.		Adrenergic Receptor
T9240	Sulfopin	Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-	Others
	Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.		Others
T1088	Repaglinide	AG-EE 388 ZW,AG-EE 623ZW	Potassium Channel , PPAR
	Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare...		Potassium Channel , PPAR
T9263	Cim0216	N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide	TRP/TRPV Channel
	CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.		TRP/TRPV Channel
T1655	Ambrisentan	BSF-208075,BSF 208075,LU 208075	Endothelin Receptor
	Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha...		Endothelin Receptor
T2555	Aclidinium bromide	LAS 34273,LAS-W 330	AChR
	Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing li...		AChR
T0929	Docusate sodium	Aerosol OT,Dioctyl sulfosuccinate sodium salt,Bis(2-ethylhexyl) sulfosuccinate sodium salt,Constonate	Opioid Receptor , HSV
	Docusate sodium (Aerosol OT) is an orally available, over-the-counter laxative and stool softener used to treat or prevent constipation. Docusate has not been linked to serum enzyme elevations during therapy or to clinic...		Opioid Receptor , HSV
T0085L	Entecavir	BMS200475,SQ34676	HBV
	Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after the...		HBV
T1677	Montelukast	Singular	Leukotriene Receptor , Lipoxygenase , LTR
	Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury...		Leukotriene Receptor , Lipoxygenase , LTR
T6875	Lesinurad	RDEA594	OAT
	Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with seru...		OAT
T1472	Trospium chloride	Spasmex,Sanctura	AChR
	Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o...		AChR
T1677L	Montelukast sodium	MK0476	Leukotriene Receptor , LTR
	Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver i...		Leukotriene Receptor , LTR
T0078L	Lapatinib ditosylate monohydrate	Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,Tyverb	EGFR , Ferroptosis , Autophagy
	Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib ditosylate monohydrate therapy is associated w...		EGFR , Ferroptosis , Autophagy