Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 319.00 | |
50 mg | In stock | $ 572.00 | |
100 mg | In stock | $ 822.00 | |
500 mg | In stock | $ 1,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). |
Targets&IC50 | MK2:(Kiapp)330 nM |
In vitro | CMPD1 exhibits selective activity within glioblastoma cells by inhibiting tubulin polymerization[3], crucial for cell division. Contrarily, it does not affect p38 MAPK-mediated phosphorylation of substrates MBP and ATF2, indicating specificity in its action. Furthermore, it induces mitotic arrest and apoptosis in U87 cells[1], highlighting its potential therapeutic implications in targeting cancer cell proliferation and survival. |
Molecular Weight | 349.4 |
Formula | C22H20FNO2 |
CAS No. | 41179-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (157.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CMPD1 41179-33-3 MAPK MAPK activated protein kinase 2 MAP kinase activated protein kinase 2 MAPKAPK2 (MK2) inhibit Mitogen-activated protein kinase activated protein kinase 2 Inhibitor MAPKAP kinase 2 CMPD 1 CMPD-1 inhibitor