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Closantel Sodium

Catalog No. T6452 CAS 61438-64-0

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

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Closantel Sodium, CAS 61438-64-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 34.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 79.00
500 mg	In stock	$ 148.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.
In vitro	Closantel inhibits drug resistant S. aureus and E. faecium with MICs of 1 μg/mL and 1 μg/mL. Closantel inhibits MRSA and E.faecalis with MICs of 2 μg/mL and 1 μg/mL. [1] Closantel completely blocks the infection of host cells with E. chaffeensis or A. phagocytophilum, treatment of infected cells 1 day post infection with closantel clears infection in dose-dependent manner. Closantel inhibits the autokinase activities of the three E. chaffeensis sensor kinases from E. chaffeensis. [2] Closantel (50 μg/mL) causes an initial burst of contractions of much greater amplitude and frequency than normal in tissue vessel, the stimulation of amplitude and frequency lasted for nearly 15 min and is accompanied by a rise in muscle tone, which reaches a maximum at 16 min, at a level greater than 1.5 times the maximal normal amplitude. [3]
In vivo	Closantel (10 mg/kg) results in gross surface damage from 24 hours onwards in rats administrated with 25 metacercarial cysts of F. hepatica, in the form of erosion of the anterior and posterior extremities of the fluke and large-scale sloughing of the tegument on both dorsal and ventral surfaces. [3] Closantel (7.5 mg/kg) combined with broad-spectrum anthelmintic is very effective against H. contortus but ineffective against Trichostrongylus spp in lambs. [4] Closantel significantly reduces isotope levels in closantel-resistant adult Haemonchus contortus infected sheep. [5]

Molecular Weight	685.06
Formula	C22H13Cl2I2N2O2·Na
CAS No.	61438-64-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (135.8 mM)

Ethanol: 93 mg/mL (135.8 mM)

References and Literature

1. Hlasta DJ, et al. Bioorg Med Chem Lett, 1998, 8(14), 1923-1928. 2. Cheng Z, et al. Cell Microbiol, 2006, 8(8), 1241-1252. 3. Skuce PJ, et al. Parasitol Res, 1990, 76(3), 241-250. 4. Dash KM, et al. Aust Vet J, 1986, 63(1), 4-7. 5. Rothwell J, et al. Int J Parasitol, 1997, 27(3), 313-319.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Parasitic Compound Library Bioactive Compounds Library Max Anti-Bacterial Compound Library NO PAINS Compound Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Antibiotics Library Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Closantel Sodium 61438-64-0 Microbiology/Virology Parasite Antibacterial Closantel Onchocerca Inhibitor volvulus fromprotozoans chitotriosidase salicylanilide inhibit O. volvulus halogenated chitinase OvCHT1 inhibitor

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