Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 137.00 | |
25 mg | In stock | $ 277.00 | |
50 mg | In stock | $ 445.00 | |
100 mg | In stock | $ 659.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5. |
Targets&IC50 | 5-HT7 receptor:7.5 (pKi) |
In vitro | SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3]. |
In vivo | SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1]. Increased Wnt/β-catenin activity was attenuated by SB 258719 in HCC cell lines and patient-derived primary tumour tissues in the presence of 5-HT. SB 258719 also reduced tumour growth in vivo[2]. |
Molecular Weight | 338.51 |
Formula | C18H30N2O2S |
CAS No. | 195199-95-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (738.53 mM)
You can also refer to dose conversion for different animals. More
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SB 258719 195199-95-2 GPCR/G Protein Neuroscience 5-HT Receptor 5-hydroxytryptamine Receptor agonism Inhibitor inverse SB258719 hydrochloride partial apparent selective inhibit SB-258719 Serotonin Receptor affinity inhibitor