vsmc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7898	AUDA		Epoxide Hydrolase
	AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)		Epoxide Hydrolase
T4778	3-Hydroxybenzaldehyde		Others , Dehydrogenase
	3-Hydroxybenzaldehyde is a compound useful in organic synthesis.		Others , Dehydrogenase
TN1969	N-(p-Coumaroyl) serotonin		PDGFR
	N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving...		PDGFR
TQ0003	740 Y-P	740YPDGFR,PDGFR 740Y-P	PI3K , Autophagy
	740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.		PI3K , Autophagy
T3088	N-Ethylmaleimide	1-Ethyl-1H-pyrrole-2,5-dione,Ethylmaleimide,NEM	Cysteine Protease , DUB
	N-Ethylmaleimide (NEM) is a sulfhydryl reagent that is widely used in experimental biochemical studies.		Cysteine Protease , DUB
TN1683	Gentisin		DNA/RNA Synthesis
	Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.		DNA/RNA Synthesis
T28222	5-Hydroxy-1-methylhydantoin	HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor
	5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...		Bradykinin Receptor
T6S0655	Corynoxeine		ERK
	1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty.		ERK
TN2063	Physalin B	NSC-287088	Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel...		Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
T4S0999	(2S)-Isoxanthohumol	Isoxanthohumol	Virus Protease , HSV
	1. (2S)-Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol with antioxidant, anti-inflammatory, and antiangiogenic ...		Virus Protease , HSV
T13376	YS-49		RAAS , Akt , PI3K , Adrenergic Receptor
	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).		RAAS , Akt , PI3K , Adrenergic Receptor
T14942	CGP48369		RAAS
	CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats.		RAAS
T83163	Adrenomedullin (rat)
	Adrenomedullin (rat), a potent vasodilator peptide, is secreted by both endothelial cells (EC) and vascular smooth muscle cells (VSMC) [1].
TN1690	Glabrene		Others , Estrogen/progestogen Receptor , Tyrosinase
	Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contributors to the notable synergistic antioxidan...		Others , Estrogen/progestogen Receptor , Tyrosinase
T75238	YS-49 monohydrate
	YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated...