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YS-49
🥰Excellent
Catalog No. T13376Cas No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
YS-49
🥰Excellent
Purity: 99.42%
Catalog No. T13376Cas No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 2 mg | $56 | In Stock | |
| 5 mg | $92 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $429 | In Stock | |
| 100 mg | $622 | In Stock | |
| 500 mg | $1,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YS-49 is an activator of PI3K/Akt (a downstream target of RhoA). |
| In vitro | In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2]. |
| In vivo | In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2]. |
| Molecular Weight | 386.28 |
| Formula | C20H20BrNO2 |
| Cas No. | 132836-42-1 |
| Smiles | Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (25.89 mM), Sonication and heating to 60℃ are recommended. DMSO: 100 mg/mL (258.88 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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