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YS-49

YS-49
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Purity:99.42%
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YS-49

Catalog No. T13376Cas No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$56In Stock
5 mg$92In Stock
10 mg$147In Stock
25 mg$289In Stock
50 mg$429In Stock
100 mg$622In Stock
500 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Product Introduction

Bioactivity
Description
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
In vitro
In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2].
In vivo
In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2].
Chemical Properties
Molecular Weight386.28
FormulaC20H20BrNO2
Cas No.132836-42-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 10 mg/mL (25.89 mM), Sonication and heating to 60℃ are recommended.
DMSO: 100 mg/mL (258.88 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.5888 mL12.9440 mL25.8880 mL129.4398 mL
5 mM0.5178 mL2.5888 mL5.1776 mL25.8880 mL
10 mM0.2589 mL1.2944 mL2.5888 mL12.9440 mL
20 mM0.1294 mL0.6472 mL1.2944 mL6.4720 mL
DMSO
1mg5mg10mg50mg
50 mM0.0518 mL0.2589 mL0.5178 mL2.5888 mL
100 mM0.0259 mL0.1294 mL0.2589 mL1.2944 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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