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N-(p-Coumaroyl) serotonin

Catalog No. TN1969 CAS 68573-24-0

N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving vascular distensibility and in reducing cardiovascular risk.N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research

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N-(p-Coumaroyl) serotonin Chemical Structure

N-(p-Coumaroyl) serotonin, CAS 68573-24-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 293.00
100 mg	In stock	$ 438.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98.78%

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Description	N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving vascular distensibility and in reducing cardiovascular risk.N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research
In vitro	As reactive oxygen species (ROS) are implicated in the signaling of lipopolysaccharide (LPS), we examined whether CS has a suppressive effect on inflammatory cytokine generation from human monocytes in vitro. CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity. ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS. Northern blot analysis showed that LPS-induced expression of these cytokine mRNA in monocytes was suppressed by CS. NF-kappaB activation was also inhibited by CS[1]
Source	Natural Products > Fabaceae > Griffonia

Molecular Weight	322.36
Formula	C19H18N2O3
CAS No.	68573-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (69.8 mM)

References and Literature

1. Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.J Interferon Cytokine Res. 1998 Jun;18(6):423-8.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Oxidation-Reduction Compound Library Ferroptosis Compound Library RO5 Drug-like Natural Product Library Natural Product Library Cytokine Inhibitor Library

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Keywords

N-(p-Coumaroyl) serotonin 68573-24-0 Angiogenesis Tyrosine Kinase/Adaptors PDGFR VSMC aortic wall N (p Coumaroyl) serotonin inhibit anti-inflammatory distensibility Inhibitor dysfunction Platelet-derived growth factor receptor atherosclerosis N(pCoumaroyl) serotonin inhibitor

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