stroke — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7946	AER-271		Aquaporin
	AER-271 is an inhibitor of aquaporin-4.		Aquaporin
T15108	DG-041		Prostaglandin Receptor
	DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per...		Prostaglandin Receptor
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T8887	2'MeO6MF		GABA Receptor
	2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...		GABA Receptor
T21635	PD184161		MEK
	PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].		MEK
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T9820	GPI-1485	GM1485	Others
	GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.		Others
T7512	BMS-191011	BMS-A	Potassium Channel
	BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models		Potassium Channel
T6581	Methyclothiazide	Duretic,Enduron,Aquatensen	Others , Carbonic Anhydrase
	Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.		Others , Carbonic Anhydrase
T3074	CHIR 98024	CHIR98014	GSK-3 , S6 Kinase
	CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.		GSK-3 , S6 Kinase
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T0368	Cinepazide maleate	MD-67350,Vasodistal,Brendil	Calcium Channel
	Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.		Calcium Channel
T6504	Flupirtine maleate	Katadolon maleate	Potassium Channel , NMDAR , iGluR
	Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.		Potassium Channel , NMDAR , iGluR
T2368	Edoxaban Tosylate Monohydrate	DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban	Factor Xa , Thrombin
	Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.		Factor Xa , Thrombin
T1101	Minocycline hydrochloride	Minocycline HCl	HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...		HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
T6651	Safinamide mesylate	PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate	MAO , Monoamine Oxidase
	Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A.		MAO , Monoamine Oxidase
T26645	Aptiganel	CNS 1102,CNS-1102,CNS1102	NMDAR
	Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke.		NMDAR
T77442	Glenzocimab	ACT017	Others
	Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ...		Others
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK