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Edoxaban Tosylate Monohydrate

Catalog No. T2368 CAS 1229194-11-9

Synonyms: DU-176b, DU-176b tosylate Monohydrate, Lixiana, Edoxaban

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Edoxaban Tosylate Monohydrate Chemical Structure

Edoxaban Tosylate Monohydrate, CAS 1229194-11-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 88.00
50 mg	In stock	$ 116.00
100 mg	In stock	$ 162.00
500 mg	In stock	$ 397.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 99.97%

Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Targets&IC50	FXa:0.561 nM(Ki)
In vitro	In thrombosis models involving rats and rabbits, Edoxaban demonstrates a dose-dependent inhibition of thrombus formation. Edoxaban (p.o.) elicits effective anti-Xa activity and achieves high plasma drug concentrations in both rats and monkeys.
In vivo	Edoxaban (0.256 and 0.508 μM) doubles the prothrombin time in human plasma and partially activates the thromboplastin time.

Synonyms	DU-176b, DU-176b tosylate Monohydrate, Lixiana, Edoxaban
Molecular Weight	738.27
Formula	C31H40ClN7O8S2
CAS No.	1229194-11-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (126 mM)

References and Literature

1. Furugohri T, et al. J Thromb Haemost. 2008, 6(9), 1542-1549.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library EMA Approved Drug Library Approved Drug Library Coagulation and Anticoagulation Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Aging Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Dechloro Rivaroxaban CH3OCO-D-CHA-Gly-Arg-pNA acetate Edoxaban 2-Methoxyphenothiazine 5-R-Rivaroxaban Rivaroxaban-d4 O-Desmethyl apixaban sulfate sodium Asundexian

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Edoxaban Tosylate Monohydrate 1229194-11-9 Metabolism Proteases/Proteasome Thrombin Factor Xa DU-176b DU-176b tosylate Monohydrate Fxa inhibit stroke Lixiana Edoxaban DU-176b Tosylate antithrombotic thromboembolic anticoagulant Inhibitor Edoxaban tosylate Edoxaban Tosylate inhibitor

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