s4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T71516	RhlR Agonist S4
	RhlR agonist S4 is a quorum sensing modulator as an RhlR agonist.
T74891	Apratoxin S4
	Apratoxin S4 (Apra S4), a potent inhibitor of Sec61, disrupts the cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER), showcasing antiviral efficacy against select flaviviruses with IC...
T80309	Dermaseptin-S4
	Dermaseptin-S4, an antimicrobial peptide sourced from frog skin, exhibits efficacy against filamentous fungi [1].
T81843	Maximin S4
	Maximin S4, an antimicrobial peptide sourced from the toad Bombina maxima, exhibits antibacterial activity against mycoplasma [1].
T24072	Franganine	Daechuine S4
	Franganine is a 14-membered-ring cyclopeptide analgesic alkaloid.
T37655	DS44960156		DHFR
	DS44960156 is a novel selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer research.		DHFR
T16153	MS4078		ALK , Ligand for E3 Ligase
	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.		ALK , Ligand for E3 Ligase
T2340	AC1NS4RE		Tyrosinase
	It is a tyrosine kinase inhibitor.		Tyrosinase
T3274	S49076		FGFR , c-Met/HGFR , TAM Receptor
	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.		FGFR , c-Met/HGFR , TAM Receptor
T14689	BMS493	BMS-493	Phospholipase , Retinoid Receptor
	BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates ...		Phospholipase , Retinoid Receptor
T16154	MS417	GTPL7512	Epigenetic Reader Domain , HIV Protease
	MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.		Epigenetic Reader Domain , HIV Protease
T12112	MS402		Epigenetic Reader Domain
	MS402 is a novel BD1-selective BET BrD inhibitor.		Epigenetic Reader Domain
T40233	(Iso)-MS4322	(Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer)	Histone Methyltransferase
	(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits th...		Histone Methyltransferase
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
T78170	Kras4B G12D-IN-1		Ras
	Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mut...		Ras
T6967	RHPS4	RHPS 4 methosulfate,NSC714187	Apoptosis , Telomerase
	RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.		Apoptosis , Telomerase
T9146	Ms48107	Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-	Others
	MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...		Others
T13090	TAS4464 hydrochloride		E1/E2/E3 Enzyme , NEDD8
	TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).		E1/E2/E3 Enzyme , NEDD8
T40293	GPS491		Antiviral , HIV Protease
	GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.		Antiviral , HIV Protease