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TAS4464 hydrochloride

Catalog No. T13090 CAS 1848959-11-4

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TAS4464 hydrochloride Chemical Structure

TAS4464 hydrochloride, CAS 1848959-11-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 123.00
5 mg	In stock	$ 263.00
10 mg	In stock	$ 428.00
25 mg	In stock	$ 716.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,370.00
1 mL * 10 mM (in DMSO)	In stock	$ 315.00

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Purity: 98.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
Targets&IC50	NAE:0.955 nM

Molecular Weight	542.97
Formula	C21H24ClFN6O6S
CAS No.	1848959-11-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 4 mg/mL (7.37 mM), Sonication and heating to 60℃ are recommended.

DMSO: 80 mg/mL (147.34 mM), Sonication is recommended.

References and Literature

1. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library HIF-1 Signaling Pathway Compound Library Bioactive Compound Library Clinical Compound Library NO PAINS Compound Library Ubiquitination Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TAS4464 hydrochloride 1848959-11-4 Metabolism Ubiquitination E1/E2/E3 Enzyme NEDD8 TAS-4464 TAS 4464 TAS4464 TAS-4464 Hydrochloride NEDD8-activating Enzyme inhibit Inhibitor NAE TAS4464 Hydrochloride TAS-4464 hydrochloride TAS 4464 Hydrochloride inhibitor

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