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TAS4464 hydrochloride

Name: TAS4464 hydrochloride
Brand: TargetMol
SKU: T13090
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13090Cas No. 1848959-11-4

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

TAS4464 hydrochloride

🥰Excellent

Purity: 98.96%

Catalog No. T13090Cas No. 1848959-11-4

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$239	In Stock
25 mg	$479	In Stock
50 mg	$793	In Stock
100 mg	$1,370	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.96%

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COA HPLC LCMS LCMS

Product Introduction

Bioactivity

Description	TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
Targets&IC50	NAE:0.955 nM

Chemical Properties

Molecular Weight	542.97
Formula	C₂₁H₂₄ClFN₆O₆S
Cas No.	1848959-11-4
Smiles	Cl.CCOc1cccc(F)c1C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (7.37 mM), Sonication and heating to 60℃ are recommended.

DMSO: 80 mg/mL (147.34 mM), Sonication is recommended.

In Vivo Formulation

30% PEG300+70% Saline: 5 mg/mL (9.21 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8417 mL	9.2086 mL	18.4172 mL	92.0861 mL
5 mM	0.3683 mL	1.8417 mL	3.6834 mL	18.4172 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1842 mL	0.9209 mL	1.8417 mL	9.2086 mL
20 mM	0.0921 mL	0.4604 mL	0.9209 mL	4.6043 mL
50 mM	0.0368 mL	0.1842 mL	0.3683 mL	1.8417 mL
100 mM	0.0184 mL	0.0921 mL	0.1842 mL	0.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc