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TAS4464 hydrochloride

Catalog No. T13090 CAS 1848959-11-4

TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

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TAS4464 hydrochloride, CAS 1848959-11-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
Targets&IC50	NAE:0.955 nM

Molecular Weight	542.97
Formula	C21H24ClFN6O6S
CAS No.	1848959-11-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 4 mg/mL (7.37 mM), ultrasonic and warming and heat to 60°C

DMSO: 80 mg/mL (147.34 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TAS4464 hydrochloride 1848959-11-4 代谢泛素化 E1/E2/E3 Enzyme NEDD8 TAS-4464 TAS 4464 TAS4464 NEDD8-activating Enzyme inhibit Inhibitor NAE TAS-4464 hydrochloride inhibitor

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