Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS402 is a novel BD1-selective BET BrD inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 312.00 | |
100 mg | In stock | $ 531.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | MS402 is a novel BD1-selective BET BrD inhibitor. |
Targets&IC50 | BRD3 BD1:110 nM (Ki), BRD4 BD2:718 nM (Ki), BRD4 BD1:77 nM (Ki), BRD3 BD2:200 nM (Ki), BRD2 BD2:240 nM (Ki), BRD2 BD1:83 nM (Ki) |
In vitro | MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment. |
Molecular Weight | 370.83 |
Formula | C20H19ClN2O3 |
CAS No. | 1672684-68-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (60.67 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MS402 1672684-68-2 Chromatin/Epigenetic Epigenetic Reader Domain inhibit Inhibitor MS-402 MS 402 inhibitor