Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 543.00 | |
100 mg | In stock | $ 782.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 153.00 |
Description | BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. |
In vitro |
BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2]. The RARβ-selective agonist (BMS453), but not RARα- or RARγ-selective agonists (BMS753 and BMS961, respectively), significantly reduced the T47D breast cancer cell migration to levels comparable to inhibition by RA, indicating that RARβ is involved in RA-inhibited cell migration[3]. |
Synonyms | BMS 453, BMS-189453 |
Molecular Weight | 380.48 |
Formula | C27H24O2 |
CAS No. | 166977-43-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (118.27 mM)
You can also refer to dose conversion for different animals. More
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BMS453 166977-43-1 Metabolism Retinoid Receptor Inhibitor BMS 453 retinoid BMS-453 RAR/RXR inhibit BMS189453 TGFβ breast RARβ RARγ Retinoid X receptors arrest BMS-189453 cell RARα BMS 189453 Retinoic acid receptors inhibitor