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AC1NS4RE

Catalog No. T2340 CAS 1055412-47-9

It is a tyrosine kinase inhibitor.

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AC1NS4RE, CAS 1055412-47-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 272.00
100 mg	In stock	$ 488.00
1 mL * 10 mM (in DMSO)	In stock	$ 60.00

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

It is a tyrosine kinase inhibitor.

Kinase Assay

Competitor assay kits (green) are used to determine relative in vitro binding affinities of ARN-509 for the rat AR ligand binding domain (LBD), human progesterone receptor (PR) LBD, and full-length human estrogen receptor-alpha (ERα) and human glucocorticoid receptor (GR). Each hormone dose is performed in triplicate, relative error is calculated from the standard error of the mean (SEM), and binding curves are fit using a single binding site competition model (Prism statistical analysis software package) with R2>0.8. Experiments are conducted multiple times with SEM<0.3 log units from the average logIC50 value. Ki values are calculated as averages across experiments with SEM, and binding affinities are reported as a percentage relative to the tight-binding ligand control for that receptor[1].

Molecular Weight	272.73
Formula	C15H13ClN2O
CAS No.	1055412-47-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.73 mg/mL (10.01 mM)

References and Literature

1. Rizzi, E., Cassinelli, G., Dallavalle, S., Lanzi, C., Cincinelli, R., & Nannei, R. et al. (2007). Synthesis and RET protein kinase inhibitory activity of 3-arylureidobenzylidene-indolin-2-ones. Bioorganic & Medicinal Chemistry Letters, 17(14), 3962-3968. doi: 10.1016/j.bmcl.2007.04.091 2. Sun, L., Tran, N., Tang, F., App, H., Hirth, P., McMahon, G., & Tang, C. (1998). Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases. Journal Of Medicinal Chemistry, 41(14), 2588-2603. doi: 10.1021/jm9820123i

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library ReFRAME Related Library Protease Inhibitor Library Covalent Inhibitor Library Bioactive Compound Library Apoptosis Compound Library Kinase Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max

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You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC1NS4RE 1055412-47-9 Proteases/Proteasome Tyrosinase Cluster of differentiation antigen 135 (Z)-SU5614 CD135 Fms like tyrosine kinase 3 inhibit AC-1NS4RE FLT3 Apoptosis Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.