plk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16560	Poloxin		PLK
	Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).		PLK
T3643	HMN-176		PLK
	HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).		PLK
T10215	AAPK-25		Apoptosis , PLK , Aurora Kinase
	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...		Apoptosis , PLK , Aurora Kinase
T15454	GW843682X	GW843682	VEGFR , PLK , CDK , PDGFR , Aurora Kinase
	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).		VEGFR , PLK , CDK , PDGFR , Aurora Kinase
T14927	Centrinone	LCR-263	PLK , Aurora Kinase
	Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).		PLK , Aurora Kinase
T6282	GSK461364	GSK461364A	PLK
	GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.		PLK
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.		PLK
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T2438	HMN-214	IVX-214,HMN214	PLK
	HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.		PLK
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T6247	Onvansertib	NMS-P937,NMS-1286937	Apoptosis , PLK
	Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.		Apoptosis , PLK
T19664	ON1231320	GBO-006	Apoptosis , PLK
	ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.		Apoptosis , PLK
T22288	(1E)-CFI-400437 dihydrochloride	CFI-400437 dihydrochloride	PLK
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.		PLK
T6283	Wortmannin	SL-2052,KY-12420	ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy
	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
T2271	SBE13 Hydrochloride	SBE 13 hydrochloride,SBE 13 HCl	Apoptosis , PLK , Autophagy
	SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.		Apoptosis , PLK , Autophagy
T6019	Volasertib	BI 6727	Apoptosis , PLK
	Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).		Apoptosis , PLK
T40265	PLK1-IN-2	PLK1-IN-2
	PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.
T6173	BI 2536		Apoptosis , Epigenetic Reader Domain , PLK
	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.		Apoptosis , Epigenetic Reader Domain , PLK
T63886	PLK1-IN-4
	PLK1-IN-4 is a potent and selective inhibitor of PLK1 (IC50<0.508 nM). PLK1-IN-4 exhibits broad anti-proliferative effects on a wide range of cancer cells. PLK1-IN-4 is able to block the cell cycle in G2/M phase and indu...
T74777	PLK1-IN-6
	PLK1-IN-6, a potent and selective inhibitor of PLK1, demonstrates significant anti-proliferative activities against cancer cells with an IC50 value of 0.45 nM [1].
T64058	PLK1/BRD4-IN-1
	PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo.
T71718	Plk1 PBD-IN-143
	Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD).
T81441	PLK1/p38γ-IN-1		p38 MAPK
	PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular carcinoma and hepatoblastoma cell lines in vitro [1].		p38 MAPK
T81440	PLK1-IN-7
	PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].
T27853	LS-008	LS 008,LS008
	LS-008, a PLK/PI3K dual inhibitor, may be used for treating cancer.
T40507	BTO-1
	BTO-1 is a compound known as a Polo-like kinase (Plk) inhibitor, commonly employed for its effectiveness in regulating processes involving phosphorylation and dephosphorylation.
T69296	PHA-680626
	PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of bot...
T73449	CZS-241
	CZS-241 is an orally active, selective Polo-like Kinase (PLK) 4 inhibitor with an IC 50 of 2.6 nM that also inhibits TRKA at an IC 50 of 2.74 μM. It induces apoptosis and causes cell cycle arrest at the S/G2 phase, demon...
T24652	Poloppin
	Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-...

Compounds

Poloxin

T16560

Target: Apoptosis, PLK, Aurora Kinase

GW843682X

T15454

Synonym: GW843682

Target: VEGFR, PLK, CDK, PDGFR, Aurora Kinase

Centrinone

T14927

Synonym: LCR-263

Target: PLK, Aurora Kinase

Synonym: RO 3280,Ro5203280

Target: Kinesin, PLK

MLN0905

T2704

Synonym: PLK1 Inhibitor

Target: PLK, JAK, BTK

Synonym: IVX-214,HMN214

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

Rigosertib sodium

T5818

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

Onvansertib

T6247

Synonym: NMS-P937,NMS-1286937

Target: Apoptosis, PLK

ON1231320

T19664

Synonym: GBO-006

Target: Apoptosis, PLK

(1E)-CFI-400437 dihydrochloride

T22288

Synonym: CFI-400437 dihydrochloride

Target: PLK

Wortmannin

T6283

Synonym: SL-2052,KY-12420

Target: ATM/ATR, DNA-PK, Serine/threonin kinase, PLK, PI3K, Antibiotic, Autophagy

SBE13 Hydrochloride

T2271

Synonym: SBE 13 hydrochloride,SBE 13 HCl

Target: Apoptosis, PLK, Autophagy

Volasertib

T6019

Synonym: BI 6727

Target: Apoptosis, PLK

Target: Apoptosis, Epigenetic Reader Domain, PLK

Synonym: LS 008,LS008

Cat No.	Product Name	Species	Expression System
TMPY-04376	PLK1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.5 kDa and the accession number is P53350.
TMPY-04438	PLK1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.6 kDa and the accession number is Q07832.

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Recombinant Proteins