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Centrinone

Catalog No. T14927 CAS 1798871-30-3

Synonyms: LCR-263

Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (<a href="/target/PLK" style="display: inline; color: #c13a36">PLK</a>4; Ki:0.16 nM).

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Centrinone, CAS 1798871-30-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
5 mg	In stock	$ 135.00
10 mg	In stock	$ 221.00
25 mg	In stock	$ 549.00
50 mg	In stock	$ 977.00
100 mg	In stock	$ 1,841.00
200 mg	In stock	$ 2,247.00
1 mL * 10 mM (in DMSO)	In stock	$ 186.00

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Purity: 98.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
Targets&IC50	Aurora A:171 nM (ki), Aurora B:436.76 nM (ki), PLK4 G95L:68.57 nM (ki), PLK4:0.16 nM (ki)
In vitro	Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells and it treatment reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors[1].

Synonyms	LCR-263
Molecular Weight	633.65
Formula	C26H25F2N7O6S2
CAS No.	1798871-30-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 31 mg/mL (48.92 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wong YL. et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Epigenetics Compound Library Cell Cycle Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Tripolin A CYC-116 MK-5108 Chiauranib SCH-1473759 L 888607 Racemate Centrinone-B Aurora B inhibitor 1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Centrinone 1798871-30-3 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase PLK LCR 263 LCR-263 Polo-like Kinase (PLK) LCR263 Inhibitor inhibit inhibitor

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