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Catalog No. T14927   CAS 1798871-30-3
Synonyms: LCR-263

Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (<a href="/target/PLK" style="display: inline; color: #c13a36">PLK</a>4; Ki:0.16 nM).

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Centrinone, CAS 1798871-30-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 93.00
5 mg In stock $ 135.00
10 mg In stock $ 221.00
25 mg In stock $ 549.00
50 mg In stock $ 977.00
100 mg In stock $ 1,841.00
200 mg In stock $ 2,247.00
1 mL * 10 mM (in DMSO) In stock $ 186.00
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Purity: 98.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
Targets&IC50 Aurora A:171 nM (ki), Aurora B:436.76 nM (ki), PLK4 G95L:68.57 nM (ki), PLK4:0.16 nM (ki)
In vitro Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells and it treatment reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors[1].
Synonyms LCR-263
Molecular Weight 633.65
Formula C26H25F2N7O6S2
CAS No. 1798871-30-3


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 31 mg/mL (48.92 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wong YL. et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Epigenetics Compound Library Cell Cycle Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
Tripolin A CYC-116 MK-5108 Chiauranib SCH-1473759 L 888607 Racemate Centrinone-B Aurora B inhibitor 1

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Centrinone 1798871-30-3 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase PLK LCR 263 LCR-263 Polo-like Kinase (PLK) LCR263 Inhibitor inhibit inhibitor