Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (<a href="/target/PLK" style="display: inline; color: #c13a36">PLK</a>4; Ki:0.16 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 135.00 | |
10 mg | In stock | $ 221.00 | |
25 mg | In stock | $ 549.00 | |
50 mg | In stock | $ 977.00 | |
100 mg | In stock | $ 1,841.00 | |
200 mg | In stock | $ 2,247.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 186.00 |
Description | Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM). |
Targets&IC50 | Aurora A:171 nM (ki), Aurora B:436.76 nM (ki), PLK4 G95L:68.57 nM (ki), PLK4:0.16 nM (ki) |
In vitro | Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells and it treatment reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors[1]. |
Synonyms | LCR-263 |
Molecular Weight | 633.65 |
Formula | C26H25F2N7O6S2 |
CAS No. | 1798871-30-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 31 mg/mL (48.92 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Centrinone 1798871-30-3 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase PLK LCR 263 LCR-263 Polo-like Kinase (PLK) LCR263 Inhibitor inhibit inhibitor