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(1E)-CFI-400437 dihydrochloride

Catalog No. T22288 CAS 1247000-76-5

Synonyms: CFI-400437 dihydrochloride

CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (<a href="/target/PLK" style="display: inline; color: #c13a36">PLK</a>4) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(1E)-CFI-400437 dihydrochloride, CAS 1247000-76-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 94.00
5 mg	In stock	$ 194.00
10 mg	In stock	$ 293.00
25 mg	In stock	$ 587.00
50 mg	In stock	$ 896.00
100 mg	In stock	$ 1,297.00
200 mg	In stock	$ 1,868.00
500 mg	In stock	$ 3,549.00

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Purity: 98.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.
Targets&IC50	PLK3:0.6 nM (IC50)

Synonyms	CFI-400437 dihydrochloride
Molecular Weight	565.5
Formula	C29H30Cl2N6O2
CAS No.	1247000-76-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Suri A , Bailey A W , Tavares M T , et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer[J]. International Journal of Molecular Sciences, 2019, 20(9).

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Kinase Inhibitor Library Inhibitor Library Cell Cycle Compound Library

Related Products

Related compounds with same targets

7-O-Prenylscopoletin CFI-400945 free base TAK-960 BI 2536 MLN0905 Ro3280 (1E)-CFI-400437 dihydrochloride ON1231320

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(1E)-CFI-400437 dihydrochloride 1247000-76-5 Cell Cycle/Checkpoint PLK antiproliferative Inhibitor Polo-like Kinase (PLK) anticancer cells MCF-7 (1E) CFI 400437 dihydrochloride PLK4 inhibit (1E)CFI400437 dihydrochloride CFI-400437 dihydrochloride inhibitor

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