nvp — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9806	NVP-DKY709		Others
	NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.		Others
T2680	NVP-BVU972		c-Met/HGFR
	NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.		c-Met/HGFR
T6348	NVP-BHG712		Raf , Bcr-Abl , Src , Ephrin Receptor
	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respecti...		Raf , Bcr-Abl , Src , Ephrin Receptor
T6294	NVP-BSK805 2HCl (1092499-93-8(free base))	NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride)	Tyrosine Kinases , JAK
	NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.		Tyrosine Kinases , JAK
T1933	NVP 231		Apoptosis , ERK
	NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.		Apoptosis , ERK
T16363	NVP-2		Apoptosis , CDK
	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...		Apoptosis , CDK
T6080	NVP-AEW541	AEW541	FLT , Tyrosine Kinases , IGF-1R , Autophagy
	NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.		FLT , Tyrosine Kinases , IGF-1R , Autophagy
TQ0231	NVP-CGM097	CGM097	Mdm2 , E1/E2/E3 Enzyme
	NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).		Mdm2 , E1/E2/E3 Enzyme
T3261	NVP-TNKS656	TNKS656	Apoptosis , PARP , Wnt/beta-catenin
	NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.		Apoptosis , PARP , Wnt/beta-catenin
TQ0068	NVP-LCQ195	AT9311,LCQ-195	CDK
	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).		CDK
T3463	NVP-ACC789	ACC-789,ZK202650	VEGFR , PDGFR
	ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.		VEGFR , PDGFR
T6079	NVP-ADW742	ADW742,ADW,GSK 552602A	Apoptosis , IGF-1R
	NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.		Apoptosis , IGF-1R
T19487	NVP-BHG712 isomer		Ephrin Receptor
	NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.		Ephrin Receptor
T3641	NVP-BAW2881	BAW2881	Raf , VEGFR , Bcr-Abl
	NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.		Raf , VEGFR , Bcr-Abl
T6118	NVP-HSP990	HSP990	Apoptosis , HSP
	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).		Apoptosis , HSP
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
T2114	VER-82576	NVP-BEP800	HSP
	VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.		HSP
T2251	NVP-TAE 684	TAE684	Apoptosis , ALK
	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).		Apoptosis , ALK
T5555	Siremadlin	NVP-HDM 201	E1/E2/E3 Enzyme
	Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.		E1/E2/E3 Enzyme
T39858	NVP-BSK805 trihydrochloride	NVP-BSK805 trihydrochloride
	NVP-BSK805 trihydrochloride is a potent ATP-competitive inhibitor of JAK2, exhibiting IC50 values of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM against JAK2 JH1, JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.