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NVP-BAW2881

Catalog No. T3641 CAS 861875-60-7

Synonyms: BAW2881

NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.

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NVP-BAW2881, CAS 861875-60-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 223.00
50 mg	In stock	$ 360.00
100 mg	In stock	$ 522.00
500 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 99.97%

Purity: 98.07%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Targets&IC50	VEGFR2 (human):9 nM, B-Raf (V599E):76 nM, VEGF2 (mouse):165 nM, c-ABL:99 nM, C-Raf1:24 nM
Cell Research	HUVECs or LECs (1.2×103) were seeded into fibronectin-coated 96-well plates. After 24 hours, the cells were transferred into LEC medium containing 2% fetal bovine serum and incubated for an additional 24 hours. Cells(eight wells/condition) were incubated with medium alone(control), 20 ng/ml VEGF-A, or a combination of 20 ng/ml VEGF-A and 1 nmol/L to 1 mol/L NVP-BAW2881. Proliferation was also assayed in LECs incubated with 500 ng/ml VEGF-C. The dimethyl sulfoxide concentration was adjusted to 0.1% in all wells. After 72 hours, cells were incubated with 5-methylumbelliferylheptanoate for subsequent fluorescent quantification of viable cells, using a SpectraMax Gemini electron microscope. (Only for Reference)

Synonyms	BAW2881
Molecular Weight	424.38
Formula	C22H15F3N4O2
CAS No.	861875-60-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 78 mg/mL (183.8 mM)

Ethanol: 16 mg/mL (37.7 mM)

References and Literature

1. Bold G, et al. J Med Chem. 2016,59(1):132-46. 2. Weidemann AK, et al. Clin Cosmet Investig Dermatol. 2013, 6:233-44. 3. Halin C, et al. Am J Pathol. 2008, 173(1):265-77.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Fibrosis Compound Library Immunology/Inflammation Compound Library Anti-Obesity Compound Library Anti-Cardiovascular Disease Compound Library Cytokine Inhibitor Library Reprogramming Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP-BAW2881 861875-60-7 Angiogenesis Cytoskeletal Signaling MAPK Tyrosine Kinase/Adaptors VEGFR Raf Bcr-Abl NVP-BAW-2881 NVPBAW2881 inhibit NVP BAW2881 Vascular endothelial growth factor receptor Inhibitor BAW 2881 BAW2881 NVP-BAW 2881 BAW-2881 inhibitor

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