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NVP-LCQ195

Catalog No. TQ0068 CAS 902156-99-4

Synonyms: AT9311, LCQ-195

NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NVP-LCQ195, CAS 902156-99-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 472.00
50 mg	In stock	$ 693.00
100 mg	In stock	$ 988.00
500 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 166.00

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Purity: 100%

Purity: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
Targets&IC50	CDK7-CyclinH-MAT1:3564 nM, CDK1-CyclinB:2 nM, CDK9-CyclinT1:15 nM, CDK2-CyclinE:5 nM, CDK3-CyclinE:42 nM, CDK5-p25:1 nM, CDK2-CyclinA:2 nM, CDK5-p35:1 nM, CDK6-CyclinD3:187 nM
In vitro	NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4[1].
In vivo	Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells[1].

Synonyms	AT9311, LCQ-195
Molecular Weight	460.33
Formula	C17H19Cl2N5O4S
CAS No.	902156-99-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (217.24 mM)

H2O: Insoluble

References and Literature

1. McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library Bioactive Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP-LCQ195 902156-99-4 Cell Cycle/Checkpoint CDK NVPLCQ195 AT9311 AT-9311 inhibit Cyclin dependent kinase Inhibitor NVP LCQ195 LCQ 195 LCQ-195 NVP-LCQ-195 LCQ195 AT 9311 NVP-LCQ 195 inhibitor

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