Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 131.00 | |
25 mg | In stock | $ 275.00 | |
50 mg | In stock | $ 468.00 | |
100 mg | In stock | $ 686.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor. |
Targets&IC50 | TNKS2:6 nM |
In vitro | In vitro, NVP-TNKS656 shows low to moderate microsomal ER values across species and high solubility. [1] In PI3K or AKT inhibitor-resistant cells, NVP-TNKS656 blocks Wnt/β-Catenin pathway and promotes apoptosis. [2] |
In vivo | In mice, NVP-TNKS656 displays low clearance and volume of distribution, and exhibits good exposure and moderate oral bioavailability. In MMTV-Wnt1 tumor bearing athymic nude mice, NVP-TNKS656 (350 mg/kg, p.o.) stabilizes Axin1 protein and reduces the Wnt/beta-catenin target gene Axin2 mRNA level by 70-80%. [1] In colorectal cancer PDX models, NVP-TNKS656 reduces nuclear β-catenin, reverts such resistance, and represses tumor growth. [2] |
Synonyms | TNKS656 |
Molecular Weight | 494.58 |
Formula | C27H34N4O5 |
CAS No. | 1419949-20-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93 mg/mL (188 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 10 mg/mL(20.21 mM), warming
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NVP-TNKS656 1419949-20-4 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Stem Cells PARP Wnt/beta-catenin NVPTNKS656 Inhibitor inhibit poly ADP ribose polymerase NVP TNKS656 TNKS656 NVP-TNKS-656 NVP-TNKS 656 TNKS-656 TNKS 656 inhibitor