Search Result

Search Results for " hsp90 "

Targets

132

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T13725	Hsp90-Cdc37-IN-1		Others
	Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.		Others
T73011	HSP90-IN-20
	HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.
T63205	HSP90-IN-13
	HSP90-IN-13 (compound 5k) is a potent broad-spectrum inhibitor of HSP90 with an IC50 of 25.07 nM. HSP90-IN-13 has multitargeted activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 blocks the MCF-7 cell cycle ...
T73037	HSP90-IN-18
	HSP90-IN-18 is a potent inhibitor of heat shock protein 90 (Hsp90), demonstrating significant inhibitory activity with an IC50 value of 0.39 μM. It is applicable in the research of viral infections, neurodegenerative dis...
T61938	HSP90-IN-12
	Vibsanin A analog C (VAC) is an anti-cancer compound, which shows anti-proliferative effect on various cancer cell lines, and the anti-proliferative activity is the strongest among vibsanin A analogues. VAC fluctuated th...
T78863	HSP90-IN-25		HSP
	HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].		HSP
T63528	HSP90-IN-11
	HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cel...
T63828	Hsp90-IN-16
	Hsp90-IN-16 is an HSP90 inhibitor that acts effectively and highly selectively on HER2-positive cancer cells.Hsp90-IN-16 inhibits the proliferation of HCC1954 breast cancer cells with an IC50 value of 6 μM.Hsp90-IN-16 in...
T79083	HSP90-IN-22		HSP
	HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKBr3 breast cancer cells.		HSP
T73038	HSP90-IN-19		HSP
	HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with an IC50 of 0.27 μM. It is utilized in the research of viral infections, neurodegenerative diseases, and inflammation...		HSP
T78942	HSP90-IN-23		HSP
	HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrests their cell cycle at the G0/G1 phase, making it applicable...		HSP
T27991	MDK-0757	Hsp90-IN-89,MDK0757
	MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).
T62307	Aha1/Hsp90-IN-1
	Aha1/Hsp90-IN-1 (Compound 17) is an inhibitor of the Aha1/Hsp90 complex and has an inhibitory effect on tau protein aggregation.Aha1/Hsp90-IN-1 disrupts the Aha1/Hsp90 interaction (IC50: 3.32 μM).
T63529	HDAC/HSP90-IN-3
	HDAC/HSP90-IN-3 is a selective and potent dual inhibitor of fungal Hsp90 (IC50: 0.83 μM) and HDAC (IC50: 0.91 μM), exhibiting antifungal effects against azole-resistant Candida albicans. HDAC/HSP90-IN-3 exhibits inhibito...
T62163	Hsp90-IN-15
	Hsp90-IN-15 is an Hsp90 inhibitor with anticancer effects. Hsp90-IN-15 blocks the cell cycle in S phase, induces apoptosis and reduces Hsp90 expression in Hela cells.
T82166	HSP90-IN-27		HSP
	HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].		HSP
T63827	HSP90-IN-10
	HSP90-IN-10 is a potent inhibitor of HSP90. HSP90-IN-10 exhibits potent anti-proliferative effects on HCC1954 breast cancer cells (IC50: 6 μM). hSP90-IN-10 induces apoptosis without inhibiting the growth of normal epithe...
T72996	Hsp90-IN-17
	Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.
T61904	HSP90-IN-14
	HSP90-IN-14 (compound 4) is an effective Hsp90 inhibitor (Kd=0.26 μM). In MDCK cells, HSP90-IN-14 showed anti-influenza virus activity, the EC50 against influenza A/H3N2, A/H1N1 and B virus was 2.6, 3.9 and 17 μM, respec...
T64263	HSP90-IN-9
	HSP90-IN-9 is a selective and potent HSP90 inhibitor.HSP90-IN-9 exhibits a dose-dependent fungicidal effect.HSP90-IN-9 in combination with FLC inhibits fungal biofilm formation and fungal morphological changes.HSP90-IN-9...
T63531	HDAC6/HSP90-IN-1
	HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM).HDAC6/HSP90-IN-1 downregulates PD-L1 expression in INF-γ-treated H1975 lung cancer cells.HDAC6/HSP90-IN-1 exhibi...
T64261	HDAC/HSP90-IN-4
	HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibit...
T72225	Hsp90-IN-17 hydrochloride
	Hsp90-IN-17 (Example 5) hydrochloride, an HSP90 inhibitor, has potential applications in the research of proliferative conditions including cancer and neurodegenerative diseases.
T72780	HSP90/mTOR-IN-1
	HSP90/mTOR-IN-1 is an effective and orally administrable inhibitor targeting both Hsp90 and mTOR, displaying IC50 values of 69 nM and 29 nM, respectively. This compound inhibits the proliferation of SW780 cells by overly...
T61315	HDAC6/HSP90-IN-2
	HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor targeting HDAC6 and Hsp90, exhibiting IC50 values of 105.7 nM and 61 nM, respectively. It is primarily utilized in cancer research [1].
T73835	PROTAC HSP90 degrader BP3
	PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of ...
T79486	MAO A/HSP90-IN-1		Monoamine Oxidase
	MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90...		Monoamine Oxidase
T79487	MAO A/HSP90-IN-2		Monoamine Oxidase
	MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phosph...		Monoamine Oxidase
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T9202	DDO-5936		HSP
	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.		HSP
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T6442	CH5138303		HSP
	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.		HSP
T79323	PROTAC Hsp90α degrader 1		HSP
	Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell line...		HSP
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T2258	VER-50589	VER50589	Apoptosis , HSP
	VER-50589 is a potent HSP90 inhibitor.		Apoptosis , HSP
T3454	VER-49009	CCT 129397	HSP
	VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).		HSP
T20890	Alvespimycin	17-DMAG,KOS1022,KOS 1022,KOS-1022	HSP
	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.		HSP
T2268	VER49009	CCT0129397,VER 49009,VER-49009	HSP
	VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).		HSP
T6305	SNX2112	SNX-2112,PF 04928473,SNX 2112	HSP
	SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.		HSP
T6248	XL888		HSP
	XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis....		HSP
T6297	Alvespimycin hydrochloride	BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl	Apoptosis , HSP
	Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.		Apoptosis , HSP
T27193	DN401	DN 401,DN-401	HSP
	DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.		HSP
T36123	3-Phenyltoxoflavin	ZINC267655,Phenyltoxoflavin	HSP
	3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.		HSP
T6960	PU-H71		HSP
	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.		HSP
T13547L	AMP-PCP disodium		HSP
	AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contributes to the formation of an active homodimer of Hsp90.		HSP
T2114	VER-82576	NVP-BEP800	HSP
	VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.		HSP
T4342	PF-04929113 Mesylate	PF-04929113 (Mesylate),SNX-5422 Mesylate	HSP , HER
	PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).		HSP , HER
T2286	BIIB021	BIIB 021,CNF2024,BIIB-021	HSP , Autophagy
	BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).		HSP , Autophagy
T6284	Onalespib	AT13387,Onalespib (AT13387)	HSP
	Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chap...		HSP
T1989	Luminespib	AUY922,VER-52296,NVP-AUY922	Apoptosis , HSP , Autophagy
	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).		Apoptosis , HSP , Autophagy

Compounds

Synonym: Hsp90-IN-89,MDK0757

Hsp90-IN-17 hydrochloride

PROTAC HSP90 degrader BP3

Target: Monoamine Oxidase

MAO A/HSP90-IN-2

T79487

Synonym:

Target: Monoamine Oxidase

PROTAC Hsp90α degrader 1

Target: Apoptosis, HSP

Synonym: 17-DMAG,KOS1022,KOS 1022,KOS-1022

Target: HSP

VER49009

T2268

Synonym: CCT0129397,VER 49009,VER-49009

Target: HSP

SNX2112

T6305

Synonym: SNX-2112,PF 04928473,SNX 2112

Alvespimycin hydrochloride

T6297

Synonym: BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl

Target: Apoptosis, HSP

DN401

T27193

Synonym: DN 401,DN-401

Target: HSP

3-Phenyltoxoflavin

T36123

Synonym: ZINC267655,Phenyltoxoflavin

Synonym: PF-04929113 (Mesylate),SNX-5422 Mesylate

Target: HSP, HER

BIIB021

T2286

Synonym: BIIB 021,CNF2024,BIIB-021

Target: HSP, Autophagy

Onalespib

T6284

Synonym: AT13387,Onalespib (AT13387)

Target: HSP

Luminespib

T1989

Synonym: AUY922,VER-52296,NVP-AUY922

Target: Apoptosis, HSP, Autophagy

Cat No.	Product Name	Synonyms	Targets
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T6343	Geldanamycin	NSC 122750	HSP , Influenza Virus , Tyrosine Kinases , Antibacterial , Antibiotic
	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T6290	Tanespimycin	17-AAG,CP 127374,NSC 330507,KOS 953	Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T8189	Dihydroberberine		Potassium Channel , HSP , HER
	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti...		Potassium Channel , HSP , HER
T5826	Eupalinolide A		HSP
	Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.		HSP
TJS0928	Calenduloside E	Silphioside F	Others
	Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intesti...		Others
T0974	Novobiocin Sodium	Albamycinsodium,Cathomycin,Albamycin	Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T16719	Radicicol	Monorden	HSP
	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and pr...		HSP
T5136	Kongensin A
	Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
TN2360	Falcarinol	Falcarinol,Panaxynol	HSP
	Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-terminal and C-terminal regions of Hsp90, displaying high selecti...		HSP
T68802	Vibsanin A
	Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.

Natural Products

Target: HSP, Influenza Virus, Tyrosine Kinases, Antibacterial, Antibiotic

Tanespimycin

T6290

Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953

Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy

Dihydroberberine

T8189

Synonym:

Target: Potassium Channel, HSP, HER

Synonym: Silphioside F

Target: Others

Novobiocin Sodium

T0974

Synonym: Albamycinsodium,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Synonym: Falcarinol,Panaxynol

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01478	HSP90 alpha Protein, Human, Recombinant	Human	E. coli
	HSP90 alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.6 kDa and the accession number is K9JA46.
TMPY-06846	HSP90 alpha Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	HSP90 alpha Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.19 kDa and the accession number is NP_032328.2.
TMPY-06845	HSP90 alpha Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	HSP90 alpha Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.06 kDa and the accession number is NP_005339.3.
TMPH-01429	HSP90AA1 Protein, Human, Recombinant (His)	Human	E. coli
	HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900.
TMPH-03113	HSP90AA1 Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	Baculovirus Insect Cells
	HSP90AA1 Protein, Pig, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 19.7 kDa and the accession number is O02705.
TMPH-01430	HSP90AB1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	HSP90AB1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 88.1 kDa and the accession number is P08238.
TMPJ-01386	STUB1 Protein, Human, Recombinant	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPJ-01411	HSPB11 Protein, Human, Recombinant (His)	Human	E. coli
	Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT2...