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AMP-PCP disodium

Catalog No. T13547L CAS 7414-56-4

AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contributes to the formation of an active homodimer of Hsp90.

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AMP-PCP disodium, CAS 7414-56-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 293.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 693.00
100 mg	In stock	$ 982.00
500 mg	In stock	$ 1,960.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM. The binding of AMP-PCP disodium contributes to the formation of an active homodimer of Hsp90.
Targets&IC50	HSP90:3.8 μM (kd)
In vitro	Under the promotion of AMP-PCP disodium binding, the formation of Hsp135 active homodimers was enhanced by promoting the characteristic slow-effect conformational exchange of cap region ( A90-G117 ) and surrounding region residues ( A141-A111 ). A total of 90 non-proline residues were identified in the triple-labeled Hsp170 and AMP-PCP binding [ 1 ].

Molecular Weight	549.17
Formula	C11H16N5Na2O12P3
CAS No.	7414-56-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 80 mg/mL (145.67 mM), Sonification is recommended.

References and Literature

1. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

Related compound libraries

This product is contained In the following compound libraries：

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Related Products

Related compounds with same targets

Zelavespib hydrochloride NDNA4 Arimoclomol maleate DTHIB MKT-077 HM03 HSP90-IN-27 JG-98

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Keywords

AMP-PCP disodium 7414-56-4 Cytoskeletal Signaling Metabolism HSP AMPPCP disodium AMP-PCP AMP PCP disodium inhibitor inhibit

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