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Alvespimycin

Catalog No. T20890 CAS 467214-20-6

Synonyms: 17-DMAG, KOS1022, KOS 1022, KOS-1022

Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.

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Alvespimycin, CAS 467214-20-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 89.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 428.00
100 mg	In stock	$ 623.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.
Targets&IC50	HSP90:62 nM (EC50), GRP94:65 nM (EC50)
In vitro	After treatment with vehicle control or 1 μM Alvespimycin (17-DMAG) for 24 hours, CLL patient cells showed that Alvespimycin downregulated NF-κB signaling through IKKα and IKKβ[2].
In vivo	Treatment with vehicle (DMSO) or Alvespimycin(17-DMAG)(10 mg/kg) significantly prolonged the survival time of TCL1-SCID model mice[2].

Synonyms	17-DMAG, KOS1022, KOS 1022, KOS-1022
Molecular Weight	616.75
Formula	C32H48N4O8
CAS No.	467214-20-6

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (129.71 mM), Sonication is recommended.

References and Literature

1. Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15. 2. Hertlein E, et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood. 2010 Jul 8;116(1):45-53. 3. Henke A, et al. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24;8(9). pii: E77. 4. Schulze K, Imbeaud S, Letouzé E, Alexandrov LB, Calderaro J, Rebouissou S, Couchy G, Meiller C, Shinde J, Soysouvanh F, Calatayud AL, Pinyol R, Pelletier L, Balabaud C, Laurent A, Blanc JF, Mazzaferro V, Calvo F, Villanueva A, Nault JC, Bioulac-Sage P, Stratton MR, Llovet JM, Zucman-Rossi J. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015 May;47(5):505-511. doi: 10.1038/ng.3252. Epub 2015 Mar 30. PubMed PMID: 25822088; PubMed Central PMCID: PMC4587544.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alvespimycin 467214-20-6 Cytoskeletal Signaling Metabolism HSP 17-DMAG KOS1022 KOS 1022 KOS-1022 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.