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Dihydroberberine

Name: Dihydroberberine
Brand: TargetMol
SKU: T8189
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8189Cas No. 483-15-8

Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interaction with hERG.

Dihydroberberine

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Purity: 99.86%

Catalog No. T8189Cas No. 483-15-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$97	-	In Stock
10 mg	$172	-	In Stock
25 mg	$322	-	In Stock
50 mg	$455	-	In Stock
100 mg	$619	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Dihydroberberine AI Summary

Dihydroberberine shows significant bioactivity as an antimalarial agent, exhibiting potent in vitro activity against Plasmodium falciparum strains D6 and W2 with IC50 values of 0.12 µg/mL and 0.171 µg/mL, respectively. In vivo studies on Plasmodium berghei parasitized mice demonstrate an improvement in mean survival time by decreasing it by 0.2 days at a dosage of 40 mg/kg. The compound displays cytotoxicity against MRC5 cells (CC50 = 155,000 nM) and antiviral activity against HCMV in MRC5 cells (IC50 = 93,000 nM) with a selectivity index of 1.7. Additionally, Dihydroberberine demonstrates high IC50 values (>200 µg/mL) for HIV1 reverse transcriptase inhibition. It also exhibits low aqueous solubility (<1000 µg/mL), moderate stability in acidic conditions (17%), and poor oral bioavailability (F = 2.65%). As an antidiabetic agent, it displays varying levels of activity in C57BLKS/J-db/db mice (12%-25%) but also shows toxicity, causing a reduction in liver weight and an increase in subcutaneous fat (11%-14%). The compound exhibits antiparasitic activity against Toxoplasma gondii ATCC 50839, inhibiting tachyzoite replication with an ID50 of 0.65 µM and demonstrating cytotoxicity against human fibroblasts with a TD50 of 41 µM. Furthermore, its therapeutic index is 63, indicating a potential selectivity advantage. Dihydroberberine also inhibits Sus scrofa pancreatic lipase type 2 with an IC50 of 8 µg/mL using PNPB as a substrate in a pre-incubation assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	337.37
Formula	C₂₀H₁₉NO₄
Cas No.	483-15-8
Smiles	COc1ccc2C=C3N(CCc4cc5OCOc5cc34)Cc2c1OC
Relative Density.	1.37 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.38 mg/mL (10.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9641 mL	14.8205 mL	29.6410 mL	148.2052 mL
5 mM	0.5928 mL	2.9641 mL	5.9282 mL	29.6410 mL
10 mM	0.2964 mL	1.4821 mL	2.9641 mL	14.8205 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc