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Novobiocin Sodium

Catalog No. T0974 CAS 1476-53-5

Synonyms: Albamycinsodium, 新生霉素钠, Cathomycin, Albamycin

Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.

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Novobiocin Sodium, CAS 1476-53-5

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.
Targets&IC50	HSP90:700 μM (IC50)
In vitro	Novobiocin also interacts with Hsp90, altering the affinity of the chaperone for geldanamycin and radicicol and causing in vitro and in vivo depletion of key regulatory Hsp90-dependent kinases including v-Src, Raf-1, and p185(ErbB2). Novobiocin interferes with association of the co-chaperones Hsc70 and p23 with Hsp90. [1] Novobiocin specifically inhibits the maturation of the heme-regulated eIF2alpha kinase (HRI) in a concentration-dependent manner. Novobiocin induces the dissociation of Hsp90 and Cdc37 from immature HRI, while the Hsp90 cochaperones p23, FKBP52, and protein phosphatase 5 remained associated with immature HRI. [2] Novobiocin causes morphological and biochemical changes which lead to induction of cell death exhibiting characteristic features of metazoan apoptosis. [3] Novobiocin, a HSP90 inhibitor, could decrease the expression of SMYD3 and dose dependently inhibit the proliferation and migration of MDA-MB-231 human breast cancer cells. Novobiocin can inhibit the migration of breast cancer cells and such event may involve the downregulation of SMYD3. [4] Novobiocin, an aminocoumarin antibiotic, interferes with heat shock protein 90 and hypoxia inducible factor dependent gene expression and thus compromises cell survival. Novobiocin (500 礛) results in a significant increase of [Ca(2+)]i, decrease of forward scatter, increase of annexin-V-binding and enhances ceramide formation. Novobiocin stimulates eryptosis, an effect at least in part due to entry of extracellular Ca(2+) and formation of ceramide. [5]

Synonyms	Albamycinsodium, 新生霉素钠, Cathomycin, Albamycin
Molecular Weight	634.614
Formula	C31H35N2NaO11
CAS No.	1476-53-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (47.27 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Marcu MG, et al. J Biol Chem, 2000, 275(47), 37181-37186. 2. Yun BG, et al. Biochemistry,2004, 43(25), 8217-8229. 3. Singh G, et al. Mol Biochem Parasitol,2005, 141(1), 57-69. 4. Luo XG, et al. IUBMB Life,2010, 62(3), 194-199. 5. Lupescu A, et al. Cell Physiol Biochem,2014, 33(3), 670-680.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Cardiovascular Disease Compound Library Antibiotics Library Inhibitor Library Natural Product Library for HTS Ion Channel Inhibitor Library Anti-Tumor Natural Product Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library

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Keywords

Novobiocin Sodium 1476-53-5 DNA损伤和修复离子通道微生物学自噬 ABC Antibacterial Antibiotic Autophagy DNA gyrase Potassium Channel Topoisomerase DNA/RNA Synthesis pneumococcal Albamycin K562 orally active Mutz-2 Apoptosis DNA interstrand cross-links cells Bacterial anti-infection HL60 Cathomycin Orthopoxvirus Novobiocin Albamycinsodium Inhibitor Heat shock proteins HSP inhibit anti-orthopoxvirus inhibitor

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