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Gedunin

Catalog No. T21883   CAS 2753-30-2

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.

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Gedunin Chemical Structure
Gedunin, CAS 2753-30-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 413.00
5 mg In stock $ 1,230.00
10 mg In stock $ 1,680.00
25 mg In stock $ 2,490.00
50 mg In stock $ 3,360.00
100 mg In stock $ 4,530.00
1 mL * 10 mM (in DMSO) In stock $ 1,350.00
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Purity: 99.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.
In vitro Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis.?Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities.?Gedunin treatment also inhibited sonic hedgehog signaling pathways.?Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling.?The anti-cancer effect of gedunin was further validated using xenograft mouse model.
Molecular Weight 482.57
Formula C28H34O7
CAS No. 2753-30-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (124.33 mM)

TargetMolReferences and Literature

1. Subramani R , Gonzalez E , Nandy S B , et al. Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway[J]. Oncotarget, 2016, 8(7). 2. Ah A , D E , Rh C , et al. Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy[J]. Life Sciences, 2020, 256.

Related compound libraries

This product is contained In the following compound libraries:
Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Selected Plant-Sourced Compound Library Natural Product Library Anti-Tumor Natural Product Library Natural Product Library for HTS Metabolism Compound Library Chinese Pharmacopoeia Natural Product Library RO5 Drug-like Natural Product Library Anti-Viral Compound Library

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Keywords

Gedunin 2753-30-2 Cytoskeletal Signaling Metabolism HSP HSP90 Inhibitor Heat shock proteins inhibit COVID-19 Alzheimer's disease neurodegenerative disorder inhibitor

 

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