g0/g1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T7791	Iberdomide	CC-220	Apoptosis , Ligand for E3 Ligase
	Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).		Apoptosis , Ligand for E3 Ligase
T8616	Fasentin	N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1.		transporter
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T1882	Meisoindigo	N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III	Apoptosis
	Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).		Apoptosis
T61884	C6 Ceramide	N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine	Apoptosis
	C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines.		Apoptosis
T11158	EGFR-IN-11		EGFR
	EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.		EGFR
T8494	NS-3-008 hydrochloride	NS-3-008 HCl	Others
	NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).		Others
T3805	Prim-O-glucosylcimifugin	Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF , COX , JAK , NO Synthase
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.		TNF , COX , JAK , NO Synthase
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T37067	9-hydroxy Stearic Acid		HDAC
	9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...		HDAC
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T26194	SKLB70326	SKLB 70326,SKLB-70326
	SKLB70326 is a cell-cycle progression inhibitor that acts by inducing G0/G1 phase arrest and apoptosis in human hepatic carcinoma cells.
T30214	Austrocortirubin	NSC626307,(+)-Austrocortirubin,NSC 626307,NSC-626307
	Austrocortirubin is a DNA damage inducer at the G0/G1, S, and G2 cell cycle stages distinct from other DNA damage agents.
T63594	Topoisomerase IIα-IN-3
	Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.
T72722	Physachenolide C		Epigenetic Reader Domain
	Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].		Epigenetic Reader Domain
T79474	GSPT1 degrader-1		Apoptosis
	GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces G0/G1 phase arrest and apoptosis in cells [1].		Apoptosis
T61412	Anticancer agent 47
	Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has ex...
T63352	BRD4 Inhibitor-18
	BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/...