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Iberdomide

Catalog No. T7791   CAS 1323403-33-3
Synonyms: CC-220

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

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Iberdomide Chemical Structure
Iberdomide, CAS 1323403-33-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
2 mg In stock $ 55.00
5 mg In stock $ 97.00
10 mg In stock $ 172.00
25 mg In stock $ 343.00
50 mg In stock $ 612.00
100 mg In stock $ 966.00
200 mg In stock $ 1,290.00
1 mL * 10 mM (in DMSO) In stock $ 96.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
Targets&IC50 cereblon:60 nM
In vitro Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α[1].
Synonyms CC-220
Molecular Weight 449.5
Formula C25H27N3O5
CAS No. 1323403-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (66.74 mM)

TargetMolReferences and Literature

1. Matyskiela M E , Zhang W , Man H W , et al. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos[J]. Journal of Medicinal Chemistry, 2017:acs.jmedchem.6b01921. 2. Peter, H, Schafer, et al. Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.[J]. Annals of the Rheumatic Diseases, 2017.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Human Metabolite Library Anti-Aging Compound Library Apoptosis Compound Library Drug Repurposing Compound Library Anti-Cancer Compound Library

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Keywords

Iberdomide 1323403-33-3 Apoptosis PROTAC Ligand for E3 Ligase CELMoD H929 CRBN Ligands for E3 Ligase KMS12PE KMS11 orally sub-G1 CC 220 cereblon G0/G1 U266 multiple ligase Inhibitor Thalidomide RPM-8226 MM1.R MM1.S EJM KMS128M inhibit CC220 E3 ligase-recruiting Moiety myeloma CC-220 inhibitor

 

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