Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 132.00 | |
5 mg | In stock | $ 328.00 | |
10 mg | In stock | $ 563.00 | |
25 mg | In stock | $ 891.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,670.00 | |
500 mg | In stock | $ 3,350.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 417.00 |
Description | EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. |
Targets&IC50 | EGFR (L858R/T790M/C797S):18 nM |
In vitro | EGFR-IN-11 (0.1 nM-10 µM) shows anti-proliferation with IC50s of 0.88 nM, 0.20 µM and 2.91 μM for HCC827, H1975 and A549 cells. EGFR-IN-11 (10nM-10 µM) suppresses the phosphorylation of EGFR in a concentration-dependent manner in the HCC827, H1975 and A549 cells[1]. |
Molecular Weight | 573.71 |
Formula | C29H35N9O2S |
CAS No. | 2463200-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (196.1 mM ), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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EGFR-IN-11 2463200-44-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR EGFRIN11 EGFR IN 11 inhibitor inhibit