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Search Result

Search Results for " bk "

46

Compounds

3

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T26830 BK 129 BK-129,BK129
BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.
T30481 BK 218 BK218,BK-218
BK 218 is a novel cephalosporin, which is active against streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrase, but has a higher MIC against penicillin-resistant strains. Bk-218 has dual administration...
T72905 Cyclo(RLsKDK) BK-1361
Cyclo(RLsKDK) (BK-1361) serves as a targeted inhibitor of the metalloproteinase ADAM8, demonstrating efficacy with an IC50 value of 182 nM. This compound shows promise for use in the treatment of inflammatory diseases an...
T20782 Triazinetriethanol Grotan BK,Grotan,Actane
Triazinetriethanol is a bactericidal agent used in coolant liquids.
T24986 6bK 6 bK,6-bK,IDE inhibitor 6bK,IDE-IN-6bK,IDE-inhibitor-6bK
6bK is an inhibitor of insulin degrading enzyme (IDE).
T30650 C.I. 15690 Chrome Black BK,Eriochrome Black SR
C.I. 15690 is a dye.
T8747 Levofloxacin hydrochloride DNA gyrase , Topoisomerase
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...
T83688 R 715 TFA [Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH
R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances...
T1451 Levofloxacin hydrate Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c...
T6060L Anabasine HCl BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653
Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana.
T15559 TBK1/IKKε-IN-2 IκB/IKK
TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.
T7951 TBK1/IKKε-IN-5 IκB/IKK
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
T60086 TTBK1-IN-2 N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Microtubule Associated
TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures ...
T75107 CrBKA
CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .
T39841 TBK1/IKKε-IN-6 TBK1/IKKε-IN-6
TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.
T26833 BKM-570
BKM-570, a bradykinin antagonist, causes impressive growth inhibition of lung and prostate tumors.
T40348 TTBK1-IN-1 TTBK1-IN-1
TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activi...
T38263 TBK1/IKKε-IN-4 TBK1/IKKε-IN-4
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ...
T78982 BK60106 Apoptosis
BK60106, a CD99 inhibitor, selectively targets and binds to the extracellular domain of CD99, effectively inducing apoptosis in Ewing sarcoma (ES) cells with minimal associated DNA damage [1].
T36095 Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) can be used in related research in the field of life sciences, and its product number is T36095.
T38598 CBK289001
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5b MV , TRAP 5b OX and TRAP 5a OX with IC 50 s of 125 μM, 4.21 μM and 14.2 μM, respectively.
T73322 TBK1-IN-1 IκB/IKK
TBK1-IN-1 is a specific and potent TANK-binding kinase 1 (TBK1) inhibitor (IC50: 22.4 nM) with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.
T16370 OABK hydrochloride Others
OABK hydrochloride is a small-molecule switch. It also can be used to control protein activity.
T10556 BKI-1369 EGFR
BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
T26831 BKM1644 BKM 1644,BKM-1644
BKM1644 is an effective inhibition of the proliferation of metastatic, castration-resistant PCa (mCRPC) cells.
T13097 TBK1/IKKε-IN-1 IκB/IKK
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
T36247 TBK1 control PROTAC® 4
Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T74865 BK50164
BK50164, a potent CD73 inhibitor, exhibits an IC50 of 13.089 µM and demonstrates affinity for CD99 with a KD value of 1.5 µM. This compound not only possesses antiproliferative activity but also induces apoptosis and cel...
T72808 (R)-TTBK1-IN-1
(R)-TTBK1-IN-1 is a potent, selective, and brain-penetrant inhibitor of tau tubulin kinase 1 (TTBK1), serving as an enantiomer of TTBK1-IN-1. It finds application in the research of Alzheimer’s disease and related tauopa...
T26832 BKM1740 BKM-1740,BKM 1740
BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.
T28222 5-Hydroxy-1-methylhydantoin HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419 Bradykinin Receptor
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...
T4612 NS309 EGFR , Potassium Channel , HER
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...
T3102 NS-1619 Apoptosis , Potassium Channel
NS1619 have cardio-protective effects after ischemia-reperfusion injury.
T12255 NS19504 Potassium Channel
NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].
T24137 HENA
HENA is a novel activator of large conductance, voltage- and Ca2+-gated K+ (BK) channels.
T37294 GoSlo-SR-5-69
BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).
T24065 FK-3657 FK 3657,FK3657,FR-173657,FR 173657,FR173657
FK-3657 is a non-peptide antagonist of bradykinin (BK)-B2 receptor.
TP1725 Bradykinin (1-5)
Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurr...
T40650 Dihydroisopimaric acid
Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp.
T75998 Cyclo(RLsKDK) TFA
Cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of the metalloproteinase ADAM8, demonstrating an IC50 value of 182 nM. It has shown potential for application in the treatment of inflammatory diseases and canc...
T37808 Kaliotoxin
Kaliotoxin is an inhibitor of neuronal BK-type peptide groups and specifically inhibits Kv channels and calcium-activated potassium channels. Kaliotoxin has research significance on the regulation of cell membrane potent...
T40750 12,14-Dichlorodehydroabietic acid
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, funct...
T76169 Angiotensin-converting enzyme
Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, converts inactive Angiotensin I (Ang I) to its active form, Angiotensin II (Ang II), and degrades active bradykinin (BK), functioning as a potent vasoconstrictor...
T70224 Bupivacaine tartrate
Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intra...
T83868 (±)13,14-EDT (±)13,14-Epoxydocosatrienoic Acid,(±)13,14-EpDoTrE,(±)-Dihomo-13,14-EET
(±)13,14-EDT, an oxylipin metabolite derived from adrenic acid through the cytochrome P450 (CYP) pathway, acts as a potent activator of large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat c...
T36215 17R(18S)-EpETE
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...

Compounds

BK 129
T26830
Synonym: BK-129,BK129
Target:
BK 218
T30481
Synonym: BK218,BK-218
Target:
cyclo(RLsKDK)
T72905
Synonym: BK-1361
Target:
Triazinetriethanol
T20782
Synonym: Grotan BK,Grotan,Actane
Target:
6bK
T24986
Synonym: 6 bK,6-bK,IDE inhibitor 6bK,IDE-IN-6bK,IDE-inhibitor-6bK
Target:
C.I. 15690
T30650
Synonym: Chrome Black BK,Eriochrome Black SR
Target:
Levofloxacin hydrochloride
T8747
Synonym:
Target: DNA gyrase, Topoisomerase
R 715 TFA
T83688
Synonym: [Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH
Target:
Levofloxacin hydrate
T1451
Synonym: Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Anabasine HCl
T6060L
Synonym: BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653
Target:
TBK1/IKKε-IN-2
T15559
Synonym:
Target: IκB/IKK
TBK1/IKKε-IN-5
T7951
Synonym:
Target: IκB/IKK
TTBK1-IN-2
T60086
Synonym: N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Target: Microtubule Associated
CrBKA
T75107
Synonym:
Target:
TBK1/IKKε-IN-6
T39841
Synonym: TBK1/IKKε-IN-6
Target:
BKM-570
T26833
Synonym:
Target:
TTBK1-IN-1
T40348
Synonym: TTBK1-IN-1
Target:
TBK1/IKKε-IN-4
T38263
Synonym: TBK1/IKKε-IN-4
Target:
BK60106
T78982
Synonym:
Target: Apoptosis
Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
T36095
Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
Target:
CBK289001
T38598
Synonym:
Target:
TBK1-IN-1
T73322
Synonym:
Target: IκB/IKK
OABK hydrochloride
T16370
Synonym:
Target: Others
BKI-1369
T10556
Synonym:
Target: EGFR
BKM1644
T26831
Synonym: BKM 1644,BKM-1644
Target:
TBK1/IKKε-IN-1
T13097
Synonym:
Target: IκB/IKK
TBK1 control PROTAC® 4
T36247
Synonym:
Target:
BK50164
T74865
Synonym:
Target:
(R)-TTBK1-IN-1
T72808
Synonym:
Target:
BKM1740
T26832
Synonym: BKM-1740,BKM 1740
Target:
5-Hydroxy-1-methylhydantoin
T28222
Synonym: HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419
Target: Bradykinin Receptor
NS309
T4612
Synonym:
Target: EGFR, Potassium Channel, HER
NS-1619
T3102
Synonym:
Target: Apoptosis, Potassium Channel
NS19504
T12255
Synonym:
Target: Potassium Channel
HENA
T24137
Synonym:
Target:
GoSlo-SR-5-69
T37294
Synonym:
Target:
FK-3657
T24065
Synonym: FK 3657,FK3657,FR-173657,FR 173657,FR173657
Target:
Bradykinin (1-5)
TP1725
Synonym:
Target:
Dihydroisopimaric acid
T40650
Synonym:
Target:
cyclo(RLsKDK) TFA
T75998
Synonym:
Target:
Kaliotoxin
T37808
Synonym:
Target:
12,14-Dichlorodehydroabietic acid
T40750
Synonym:
Target:
Angiotensin-converting enzyme
T76169
Synonym:
Target:
Bupivacaine tartrate
T70224
Synonym:
Target:
(±)13,14-EDT
T83868
Synonym: (±)13,14-Epoxydocosatrienoic Acid,(±)13,14-EpDoTrE,(±)-Dihomo-13,14-EET
Target:
17R(18S)-EpETE
T36215
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6567 Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin Topoisomerase , Antibacterial , Antibiotic
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
T12403 Penitrem A Others
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
T12373 Paxilline Others
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.

Natural Products

Levofloxacin
T6567
Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin
Target: Topoisomerase, Antibacterial, Antibiotic
Penitrem A
T12403
Synonym:
Target: Others
Paxilline
T12373
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (6)
BKPyV (2)
Expression System：
E. coli (5)
Baculovirus Insect Cells (2)
HEK293 Cells (1)
Tag：
C-His (2)
N-10xHis (2)
N-10xHis, C-Myc (2)
N-6xHis (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPH-00200 BK polyomavirus (BKPyV) VP1 Protein (His & Myc) BKPyV E. coli
BK polyomavirus (BKPyV) VP1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.1 kDa and the accession number is P03088.
TMPH-00201 BK polyomavirus (BKPyV) VP2 Protein (His) BKPyV E. coli
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ...
TMPY-01598 Kininogen 1 Protein, Human, Recombinant (His) Human HEK293 Cells
Kininogen 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is P01042-1.
TMPY-04769 RBKS Protein, Human, Recombinant (His) Human E. coli
RBKS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H477-1.
TMPH-01531 IKBKB Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPY-04547 PBK/TOPK Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
TMPH-02180 TTBK2 Protein, Human, Recombinant (His & Myc) Human E. coli
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother cent...
TMPH-01532 IKBKB Protein, Human, Recombinant (E. coli, His) Human E. coli
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
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