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Levofloxacin

Catalog No. T6567 CAS 100986-85-4

Synonyms: Levaquin, Cravit, Tavanic, Fluoroquinolone, (-)-Ofloxacin

Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

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Levofloxacin, CAS 100986-85-4

Pack Size	Availability	Price/USD
100 mg	In stock	$ 48.00
5 g	In stock	$ 76.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.63%

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Chemical Properties

Storage & Solubility Information

Description	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
In vitro	Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate?activity?against anaerobes.[1] Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more?active?than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.?Levofloxacin?inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. [2] Levofloxacin?exhibits twofold greater?inhibitory?and?bactericidal?activities?than ofloxacin?against?either extracellular or intracellular tubercle bacilli.?[3] Levofloxacin?has the least?inhibitory?effect on osteoblastic cell growth, with a 50%?inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis.[4] Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. [5]
In vivo	Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. [2]

Synonyms	Levaquin, Cravit, Tavanic, Fluoroquinolone, (-)-Ofloxacin
Molecular Weight	361.37
Formula	C18H20FN3O4
CAS No.	100986-85-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (34.59 mM)

Ethanol: 2 mg/mL(5.5 mM)

H2O: 9 mg/mL (24.9 mM)

References and Literature

1. Davis R, et al. Drugs,1994, 47(4), 677-700. 2. Fu KP, et al. Antimicrob Agents Chemother,1992, 36(4), 860-866. 3. Mor N, et al. Antimicrob Agents Chemother,1994, 38(5), 1161-1164. 4. Holtom PD, et al. J Orthop Res,2000, 18(5), 721-727. 5. Kato M, et al. Antimicrob Agents Chemother,1995, 39(9), 1979-1983. 6. Shen X, Zhang W, Peng C, et al. In vitro anti‐bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection[J]. Chinese medicine. 2021, 16(1): 1-19.

Citations

1. Shen X, Zhang W, Peng C, et al. In vitro anti‐bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection. Chinese medicine. 2021, 16(1): 1-19. 2. Yan J, Peng C, Chen P, et al. In-vitro anti-Helicobacter pylori activity and preliminary mechanism of action of Canarium album raeusch. Fruit extracts. Journal of Ethnopharmacology. 2021: 114578. 3. Kong Y, Geng Z, Jiang G, et al.Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China.Heliyon.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library EMA Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Inhibitor Library FDA-Approved Drug Library Natural Product Library for HTS Anti-Infection Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levofloxacin 100986-85-4 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Orthopoxvirus BK Viremia Levaquin inhibit Inhibitor Cravit DNA gyrase Tavanic airway inflammation Fluoroquinolone DNA/RNA Synthesis Bacterial Ofloxacin (-)-Ofloxacin chronic periodontitis inhibitor

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