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Levofloxacin hydrochloride

Catalog No. T8747 CAS 177325-13-2

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

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Levofloxacin hydrochloride Chemical Structure

Levofloxacin hydrochloride, CAS 177325-13-2

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1 g	In stock	$ 37.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	397.8
Formula	C18H21ClFN3O4
CAS No.	177325-13-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mM

H2O: 100 mg/mL (251.38 mM)

References and Literature

1. Schmitz FJ, et al. J Antimicrob ChemOthers. 1998 Apr;41(4):481-4. 2. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014. 3. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library Clinical Compound Library Bioactive Compounds Library Max Anti-Fibrosis Compound Library DNA Damage & Repair Compound Library Antibiotics Library

Related Products

Related compounds with same targets

Fleroxacin Tryptanthrin BRD7116 Ciprofloxacin monohydrochloride Novobiocin Sodium Alalevonadifloxacin Norfloxacin Gemifloxacin mesylate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levofloxacin hydrochloride 177325-13-2 DNA Damage/DNA Repair Topoisomerase DNA gyrase Levofloxacin DNA/RNA Synthesis airway inflammation Antibiotic BK Viremia Bacterial Inhibitor Levofloxacin Hydrochloride chronic periodontitis inhibit inhibitor

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