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Levofloxacin hydrochloride

Catalog No. T8747 CAS 177325-13-2

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

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Levofloxacin hydrochloride, CAS 177325-13-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	397.83
Formula	C18H21ClFN3O4
CAS No.	177325-13-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schmitz FJ, et al. J Antimicrob ChemOthers. 1998 Apr;41(4):481-4. 2. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014. 3. Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.

Related compound libraries

This product is contained In the following compound libraries：

Antibiotics Library Anti-Fibrosis Compound Library

Related Products

Related compounds with same targets

Zoliflodacin Levofloxacin hydrochloride Tryptanthrin BRD7116 Gemifloxacin mesylate Levofloxacin hydrate Trovafloxacin Fleroxacin

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levofloxacin hydrochloride 177325-13-2 DNA损伤和修复 DNA gyrase Topoisomerase Levofloxacin DNA/RNA Synthesis airway inflammation Antibiotic BK Viremia Bacterial Inhibitor chronic periodontitis inhibit inhibitor

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