az-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T68668	AZ-1
	AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T2689	AZ3146	AZ 3146	Kinesin
	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.		Kinesin
T2491	AZ-5104		EGFR
	AZ5104 is a potent EGFR inhibitor.		EGFR
T7685	USP25/28 inhibitor AZ1	AZ1	DUB
	USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28		DUB
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T3224	TBA-7371	AZ 7371,DprE1-IN-1	Antibacterial , PDE , DprE1
	TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.		Antibacterial , PDE , DprE1
T21659	AZ 11645373	3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE	P2X Receptor
	AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.		P2X Receptor
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R
T11876	LpxH-IN-AZ1		Antibacterial
	LpxH-IN-AZ1 is a potent inhibitor of the UDP-2,3-diacylglucosamine pyrophosphate hydrolase, LpxH, and sulfonylpiperazine compounds.LpxH-IN-AZ1 exhibits antimicrobial activity and inhibits Klebsiella pneumoniae with an IC...		Antibacterial
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK
T14365	AZ PFKFB3 26		Glucokinase
	AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.		Glucokinase
T6318	AZ 628		Apoptosis , Raf
	AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.		Apoptosis , Raf
T36374	Naloxegol (NKTR-118)
	Naloxegol (NKTR-118; AZ-13337019) is an opioid-receptor antagonist[1]. [1]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Ju...
T37412	AZ-GHS-22
	AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1It binds to GHS-R1a with an IC50value of 0.77 nM. AZ-GHS-22 decreases food intake in ...
T74060	AZ'6421
	AZ'6421, functioning as a Proteolysis Targeting Chimera (PROTAC), selectively degrades estrogen receptor alpha, demonstrating potent anti-tumor activity by inhibiting uncontrolled cellular proliferation characteristic of...