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AZ-Dyrk1B-33

Catalog No. T14364 CAS 1679330-37-0

Synonyms: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.

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AZ-Dyrk1B-33, CAS 1679330-37-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
Targets&IC50	Dyrk pS421:0.192 μM, DYRK1B:7 nM
In vitro	Administration of AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM and no effect in sensitization[1].

Synonyms	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Molecular Weight	300.36
Formula	C19H16N4
CAS No.	1679330-37-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 120 mg/mL (399.52 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

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LDN-192960 Protein kinase inhibitors 1 GNF2133 ML167 INDY EHT 1610 CLK-IN-T3 AZ-Dyrk1B-33

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ-Dyrk1B-33 1679330-37-0 蛋白酪氨酸激酶细胞周期 DYRK Dual specificity tyrosine regulated kinase kinase syndrome mechanism cells resistance stress inhibit Inhibitor metabolic response undergoing Mirk-related AZDyrk1B33 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine Minibrain-related Dyrk1B AZ Dyrk1B 33 Dual specificity tyrosine phosphorylation regulated kinase AZ-Dyrk-1B-33 osteosarcoma inhibitor

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