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AZ-Dyrk1B-33

Catalog No. T14364 CAS 1679330-37-0

Synonyms: 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine

AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.

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AZ-Dyrk1B-33, CAS 1679330-37-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 263.00
25 mg	In stock	$ 533.00
50 mg	In stock	$ 775.00
100 mg	In stock	$ 1,080.00
500 mg	In stock	$ 2,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 178.00

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Purity: 99.99%

Biological Description

Chemical Properties

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Description	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
Targets&IC50	DYRK1B:7 nM, DYRK (pS421):0.192 μM
In vitro	Administration of AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM and no effect in sensitization[1].

Synonyms	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
Molecular Weight	300.36
Formula	C19H16N4
CAS No.	1679330-37-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (399.52 mM)

References and Literature

1. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Highly Selective Inhibitor Library Bioactive Compounds Library Max Kinase Inhibitor Library Cell Cycle Compound Library Anti-Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

EHT 1610 ID-8 CLK1-IN-3 GNF2133 INDY CK2/ERK8-IN-1 DYRKs-IN-1 ARN25068

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ-Dyrk1B-33 1679330-37-0 Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors DYRK Dual specificity tyrosine regulated kinase kinase syndrome mechanism cells resistance stress inhibit Inhibitor metabolic response undergoing Mirk-related AZDyrk1B33 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine Minibrain-related Dyrk1B AZ Dyrk1B 33 Dual specificity tyrosine phosphorylation regulated kinase AZ-Dyrk-1B-33 osteosarcoma inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.