Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 126.00 | |
5 mg | In stock | $ 257.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 |
Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
Targets&IC50 | FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , MLK1:88 nM , FLT4:1784 nM , IGF-1R:1.6 μM , ERB4:195 nM , TEC:1317 nM , IRR:840 nM |
In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
Synonyms | AZ7550 hydrochloride (1421373-99-0 free base) |
Molecular Weight | 522.04 |
Formula | C27H32ClN7O2 |
CAS No. | 2309762-40-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.5 mg/mL (2.8 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
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AZ7550 hydrochloride 2309762-40-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors IGF-1R EGFR ErbB-1 Epidermal growth factor receptor HER1 Drug Metabolite AZ-7550 Hydrochloride AZ7550 Hydrochloride inhibit AZ7550 1421373-99-0 AZ-7550 1421373-99-0 free base AZ 7550 Hydrochloride AZ 7550 AZ7550 hydrochloride (1421373-99-0 free base) Inhibitor AZ-7550 hydrochloride inhibitor