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AZ7550

Catalog No. T13564   CAS 1421373-99-0

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

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AZ7550 Chemical Structure
AZ7550, CAS 1421373-99-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 133.00
5 mg In stock $ 302.00
10 mg In stock $ 447.00
25 mg In stock $ 738.00
50 mg In stock $ 987.00
100 mg In stock $ 1,380.00
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Purity: 97.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Targets&IC50 FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , MLK1:88 nM , FLT4:1784 nM , IGF-1R:1.6 μM , ERB4:195 nM , TEC:1317 nM , IRR:840 nM
In vitro AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
Molecular Weight 485.58
Formula C27H31N7O2
CAS No. 1421373-99-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Anti-Aging Compound Library HIF-1 Signaling Pathway Compound Library Reprogramming Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Cytokine Inhibitor Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets
IM-54 Cerdulatinib hydrochloride AZ7550 trimesylate salt LY-364947 (E/Z)-Necrosulfonamide Necrosulfonamide GW806742X MLKL-IN-2

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Keywords

AZ7550 1421373-99-0 Angiogenesis Cytoskeletal Signaling JAK/STAT signaling MAPK Metabolism Tyrosine Kinase/Adaptors Tyrosine Kinases IGF-1R PYK2 MNK MLK FAK EGFR FLT ACK ALK BTK Drug Metabolite Epidermal growth factor receptor inhibit Inhibitor ErbB-1 HER1 AZ 7550 AZ-7550 inhibitor

 

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